Induction of CD4 T cell memory by local cellular collectivity

被引：56

作者：

Polonsky, Michal ^{[1
]}

Rimer, Jacob ^{[1
]}

Kern-Perets, Amos ^{[1
]}

Zaretsky, Irina ^{[1
]}

Miller, Stav ^{[1
]}

Bornstein, Chamutal ^{[1
]}

David, Eyal ^{[1
]}

Kopelman, Naama Meira ^{[2
,4
]}

Stelzer, Gil ^{[2
]}

Porat, Ziv ^{[2
]}

Chain, Benjamin ^{[3
]}

Friedman, Nir ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, Rehovot, Israel

[2] Weizmann Inst Sci, Life Sci Core Facil, Rehovot, Israel

[3] UCL, Div Infect & Immun, London, England

[4] Holon Inst Technol, Dept Comp Sci, Holon, Israel

来源：

SCIENCE | 2018年 / 360卷 / 6394期

基金：

以色列科学基金会;

关键词：

LYMPHOCYTE DIVISION; CD8(+) EFFECTOR; DIFFERENTIATION; GENERATION; INFECTION; EXPANSION; ACTIVATION; EXPRESSION; IMMUNITY; SPECIFICATION;

D O I：

10.1126/science.aaj1853

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell differentiation is directed by signals driving progenitors into specialized cell types. This process can involve collective decision-making, when differentiating cells determine their lineage choice by interacting with each other. We used live-cell imaging in microwell arrays to study collective processes affecting differentiation of naive CD4+ Tcells into memory precursors. We found that differentiation of precursor memory Tcells sharply increases above a threshold number of locally interacting cells. These homotypic interactions involve the cytokines interleukin-2 (IL-2) and IL-6, which affect memory differentiation orthogonal to their effect on proliferation and survival. Mathematical modeling suggests that the differentiation rate is continuously modulated by the instantaneous number of locally interacting cells. This cellular collectivity can prioritize allocation of immune memory to stronger responses.

引用

页码：1201 / +

页数：12

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