Repurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure

被引：7
|
作者：
Tafere, Gebrehiwot Gebremedhin [1 ]
Wondafrash, Dawit Zewdu [1 ]
Demoz, Filmon Beyenne [1 ]
机构：
[1] Mekelle Univ, Sch Pharm, Dept Pharmacol & Toxicol, Mekelle, Ethiopia
来源：
HEPATIC MEDICINE-EVIDENCE AND RESEARCH | 2020年 / 12卷
关键词：
N-acetylcysteine; dengue virus; acute liver failure; CHILDREN; ENTRY;
D O I：
10.2147/HMER.S263840
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The prevalence of dengue infection-induced acute liver damage is increasing from time to time. Since it has no specific antiviral treatment in the world, people in endemic areas suffer more from dengue disorders. Thus, there is a need for searching options for the treatment of dengue-induced acute liver failure. N-acetylcysteine, which is used for the treatment of nasal congestion disorder and paracetamol overdose toxicity, could be used as a definitive therapy for dengue virus-induced acute liver disease. Therefore, this review discusses the therapeutic use of N-acetylcysteine for dengue-induced acute liver disease. Various case reports and case series showed that patients received NAC recovered from their clinical status. Additionally, a preclinical study showed that N-acetylcysteine has anti-dengue virus activity. Thus, N-acetylcysteine could be used as a definitive therapy in dengue virus-induced hepatitis. This might encourage researchers to further investigate the importance of N-acetylcysteine for dengue virus-induced hepatitis.
引用
收藏
页码：173 / 178
页数：6
相关论文
共 50 条
  • [1] Intravenous N-acetylcysteine in dengue-associated acute liver failure
    Kumarasena, Ravindu S.
    Senanayake, S. Mananjala
    Sivaraman, Krishan
    de Silva, Arjuna P.
    Dassanayake, Anuradha S.
    Premaratna, Ranjan
    Wijesiriwardena, Bandula
    de Silva, H. Janaka
    [J]. HEPATOLOGY INTERNATIONAL, 2010, 4 (02) : 533 - 534
  • [2] Intravenous N-acetylcysteine in dengue-associated acute liver failure
    Ravindu S. Kumarasena
    S. Mananjala Senanayake
    Krishan Sivaraman
    Arjuna P. de Silva
    Anuradha S. Dassanayake
    Ranjan Premaratna
    Bandula Wijesiriwardena
    H. Janaka de Silva
    [J]. Hepatology International, 2010, 4 : 533 - 534
  • [3] N-acetylcysteine in children with acute liver failure complicating dengue viral infection
    Senanayake, M. P.
    Jayamanne, M. D. C. J. P.
    Kankananarachchi, I.
    [J]. CEYLON MEDICAL JOURNAL, 2013, 58 (02) : 80 - 82
  • [4] Successful use of intravenous N-acetylcysteine in dengue haemorrhagic fever with acute liver failure
    Abeysekera, R. A.
    Illangasekera, U.
    Jayalath, T.
    Sandeepana, A. G. W.
    Kularatne, S. A. M.
    [J]. CEYLON MEDICAL JOURNAL, 2012, 57 (04) : 166 - 167
  • [5] N-Acetylcysteine in non-acetaminophen-induced acute liver failure
    Filik, Levent
    [J]. HEPATOLOGY INTERNATIONAL, 2010, 4 (02) : 535 - 535
  • [6] N-Acetylcysteine in non-acetaminophen-induced acute liver failure
    Levent Filik
    [J]. Hepatology International, 2010, 4 : 535 - 535
  • [7] N-Acetylcysteine Use in Non-Acetaminophen-Induced Acute Liver Failure
    McPheeters, Chelsey M.
    VanArsdale, Vanessa M.
    Weant, Kyle A.
    [J]. ADVANCED EMERGENCY NURSING JOURNAL, 2016, 38 (03) : 183 - 189
  • [8] A Case of Cocaine-Induced Acute Liver Failure Reversed With N-Acetylcysteine
    Mitchell, Mary C.
    Rogers, Cleon
    [J]. CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (07)
  • [9] N-acetylcysteine for non-acetaminophen induced acute liver failure: A review
    Jiang, Shirley Xue
    Hussaini, Trana
    Yoshida, Eric M.
    [J]. SAUDI JOURNAL OF GASTROENTEROLOGY, 2022, 28 (02): : 85 - 91
  • [10] Early treatment with N-acetylcysteine in children with acute liver failure secondary to hepatitis A
    Sotelo, Norberto
    de los Angeles Durazo, Maria
    Gonzalez, Alejandro
    Dhanakotti, Nagasharmila
    [J]. ANNALS OF HEPATOLOGY, 2009, 8 (04) : 353 - 358
12345