Early enteral feedings in adults receiving venovenous extracorporeal membrane oxygenation

Introduction: For over 20 years extracorporeal. membrane oxygenation (ECMO) has been an advanced treatment for adults, children and neonates with severe respiratory failure that has failed to respond or improve with conventional therapy. Withholding enteral. feeding in patients on ECMO is common practice in many centers, based partly on the risk of splanchnic ischemia resulting in loss of intestinal integrity, predisposing to bacterial translocation and sepsis. We report one center's experience with early enteral nutrition in adult patients receiving venovenous (VV) ECMO for severe respiratory failure. Methods: Adult patients that received VV ECMO at LSUHSC-Shreveport over the last 8 years were eligible for inclusion. Results: A total of 27 patients met these criteria and their charts and nutrition therapy reviewed. Average duration of ECMO support was 8.7 +/- 3.6 days. Twenty-six of 27 (96%) received enteral nutrition via gastric tube alone or in combination with total parenteral nutrition (TPN). Eighteen patients received enteral nutrition as their only source of nutritional supplementation, with the remainder receiving partial nutrition support via the parenteral route. Seventy-five percent of the patients received prokinetic medication within the first 24 hours, with 95% receiving prokinetic therapy by 48 hours. No patients developed intestinal ischemia, gastrointestinal bleeding, or other complications related to early enteral feeding. Conclusion: Enteral nutrition started within the first 24 to 36 hours of initiating venovenous ECMO support is safe and well-tolerated in adults. No serious adverse events were attributable to enteral nutrition in these patients.