One-step stereocontrolled synthesis of α-anomeric carboxylic acid esters from unprotected glycosyl donors:: A water-soluble aspirin pro-drug analogue

被引：0
|
作者：
Hanessian, S [1 ]
Mascitti, V [1 ]
Lu, PP [1 ]
Ishida, H [1 ]
机构：
[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada
来源：
SYNTHESIS-STUTTGART | 2002年 / 14期
关键词：
carbohydrates; aspirin; pro-drugs; esters; stereoselectivity;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of 2-(3-methoxypyridyl) beta-D-gluco- and D-galactopyranosides with various carboxylic acids affords the corresponding alpha-1-esters in high yields. Aspirin can be solubilized in water as the alpha-D-galactopyranosyl ester.
引用
收藏
页码：1959 / 1968
页数：10
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