Fatal Cryptococcus gattii genotype AFLP6/VGII infection in a HIV-negative patient: case report and a literature review

被引：11

作者：

Favalessa, Olivia Cometti ^{[1
]}

Lazera, Marcia dos Santos ^{[2
]}

Wanke, Bodo ^{[2
]}

Trilles, Luciana ^{[2
]}

Takahara, Doracilde Terumi ^{[1
]}

Tadano, Tomoko ^{[3
]}

Dias, Luciana Basili ^{[1
]}

Vieira, Ananda Castro ^{[3
]}

Novack, Glaucia Vanessa ^{[3
]}

Hahn, Rosane Christine ^{[1
,3
]}

机构：

[1] Univ Fed Mato Grosso, Fac Med, Lab Micol, Cuiaba, MT, Brazil

[2] Fiocruz MS, IPEC Lab Micol, BR-21045900 Rio De Janeiro, RJ, Brazil

[3] Univ Fed Mato Grosso, Hosp Univ Julio Muller, Cuiaba, MT, Brazil

来源：

MYCOSES | 2014年 / 57卷 / 10期

关键词：

Neurocryptococcosis; Cryptococcus gattii; seronegative for HIV; midwestern of Brazil; IN-VITRO SUSCEPTIBILITIES; RIO-DE-JANEIRO; VANCOUVER-ISLAND; ANTIFUNGAL SUSCEPTIBILITIES; NEOFORMANS; STATE; MENINGITIS; MANAGEMENT; FEATURES; DISEASE;

D O I：

10.1111/myc.12210

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Cryptococcus gattii, a species belonging to the Cryptococcus complex which occurs endemically in tropical and subtropical regions, has been reported as a causative agent of cryptococcosis in healthy individuals. We report a case of meningitis in HIV-negative patient from Cuiaba, MT, in the Midwestern region of Brazil. Cryptococcus gattii AFLP6/VGII was isolated from cerebrospinal fluid and molecular typing was performed by URA5-RFLP. The in vitro susceptibility profile was determined using the standard method according to the document M27A3, CLSI 2008. C. gattii AFLP6/VGII was shown to be susceptible to the antifungals tested. Treatment with 0.8mg/kg of amphotericin B was initiated; however, the patient died 2 days after the onset of therapy.

引用

页码：639 / 643

页数：5

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