Sesquiterpene lactones from Crepis cameroonica (Asteraceae)

被引：14
|
作者：
Ndom, J. C.
Mbafor, J. T.
Wansi, J. D.
Kamdem, A. W.
Meva'a, L. M.
Vardamides, J. C.
Toukam, F.
Pegyemb, D.
Ngando, T. M.
Laatsch, H.
Fomum, Z. T.
机构：
[1] Univ Douala, Fac Sci, Dept Organ Chem, Douala, Cameroon
[2] Univ Yaounde I, Dept Organ Chem, Fac Sci, Yaounde, Cameroon
[3] Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany
来源：
NATURAL PRODUCT RESEARCH | 2006年 / 20卷 / 05期
关键词：
Crepis cameroonica; Asteraceae; sesquiterpene lactone; guaianolides; zaluzanin; antimicrobial activity;
D O I：
10.1080/14786410500182300
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In addition to one known compound, 3 beta, 8 alpha-dihydroxyguaian- 4(15), 10(14), 11(13)- trien-6,12 olide (8-desacylcynaropicrin) ( 3), two new sesquiterpene lactones have been isolated from the aerial parts of Crepis cameroonica. By means of spectroscopic analysis, the structures and relative configurations of the new compounds were established as 3 beta, 9 beta-dihydroxyguaian4( 15), 10( 14), 11( 13)- trien-6,12 olide ( 1) and 8 alpha-hydroxy-4 alpha( 13), 11 beta(15)-tetrahydrozaluzanin C (2). The in vitro antimicrobial spectrum of pure compounds and crude extracts are also reported.
引用
收藏
页码：435 / 442
页数：8
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