Characterization of a Mycobacterium smegmatis mutant lacking penicillin binding protein 1

被引：25

作者：

Billman-Jacobe, H ^{[1
]}

Haites, RE ^{[1
]}

Coppel, RL ^{[1
]}

机构：

[1] Monash Univ, Dept Microbiol, Clayton, Vic 3168, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 12期

关键词：

D O I：

10.1128/AAC.43.12.3011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ponA gene of Mycobacterium smegmatis encodes a 95-kDa penicillin binding protein, PBP1, that is similar to PBP1s of Mycobacterium tuberculosis and Mycobacterium leprae. Transposon disruption of ponA in M. smegmatis resulted in a PBP1-deficient mutant that was sensitive to beta-lactam antibiotics, was more permeable to glycine, and grew slowly in liquid culture.

引用

页码：3011 / 3013

页数：3

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