Long-term remission of therapy-related acute myeloid leukemia with a new t(11;18)(q23;q21.2) translocation and KMT2A-ME2 (MLL-ME2) fusion gene

被引：0
|
作者：
Szotkowski, Tomas [1 ]
Jarosova, Marie [1 ]
Zimmermannova, Olga [2 ,3 ]
Meyer, Claus [4 ]
Marschalek, Rolf [4 ]
Zuna, Jan [2 ,3 ]
Hubacek, Jaromir [1 ]
Indrak, Karel [1 ]
机构：
[1] Palacky Univ, Fac Med & Dent, Dept Hematooncol, CR-77147 Olomouc, Czech Republic
[2] Charles Univ Prague, Dept Pediat Hematol & Oncol, CLIP, Fac Med 2, Prague, Czech Republic
[3] Univ Hosp Motol, Prague, Czech Republic
[4] Goethe Univ Frankfurt, DCAL, Dept Biochem Chem & Pharm, Inst Pharmaceut Biol, D-60054 Frankfurt, Germany
来源：
CANCER GENETICS | 2015年 / 208卷 / 12期
关键词：
Therapy-related acute myeloid leukemia; MLL gene rearrangement; inv(16); long-term remission; KMT2A; PROGNOSTIC-SIGNIFICANCE; CHROMOSOME-ABERRATIONS; AML; MLL; CYTOGENETICS; SERIES;
D O I：
10.1016/j.cancergen.2015.09.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We describe a unique case of a woman with acute myeloid leukemia with a new, previously undescribed translocation, t(11;18)(q23;q21.2), affecting the KMT2A (MLL) gene and resulting in an KMT2A(MLL)-ME2 fusion. This disease occurred secondarily following chemotherapy for a different acute myeloid leukemia with the recurrent genetic abnormality inv(16)(p13.1;q22). The secondary leukemia was treated with intensive chemotherapy without allogeneic hematopoietic cell transplantation. Complete remission lasting more than 10 years has been achieved with concurrent and sustained remission of the primary leukemia.
引用
收藏
页码：610 / 614
页数：5
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