Circadian rhythm in negative affect: Implications for mood disorders

被引：23

作者：

Emens, Jonathan S. ^{[1
,2
,3
]}

Berman, Alec M. ^{[2
]}

Thosar, Saurabh S. ^{[2
,4
,6
]}

Butler, Matthew P. ^{[2
,5
]}

Roberts, Sally A. ^{[2
]}

Clemons, Noal A. ^{[2
]}

Herzig, Maya X. ^{[2
]}

McHill, Andrew W. ^{[2
]}

Morimoto, Miki ^{[2
]}

Bowles, Nicole P. ^{[2
]}

Shea, Steven A. ^{[2
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Psychiat, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[2] Oregon Inst Occupat Hlth Sci, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[3] VA Portland Hlth Care Syst, 3710 SW US Vet Hosp Rd,Mailcode P3-MHADM, Portland, OR 97239 USA

[4] Oregon Hlth & Sci Univ, Sch Nursing, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[5] Oregon Hlth & Sci Univ, Dept Behav Neurosci, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[6] Oregon Hlth & Sci Univ, Dept Med, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

来源：

PSYCHIATRY RESEARCH | 2020年 / 293卷

基金：

美国国家卫生研究院;

关键词：

Circadian; Mood disorders; Sleep; SLEEP; MELATONIN; MISALIGNMENT; ENTRAINMENT; VALIDATION; MARKER; CYCLE;

D O I：

10.1016/j.psychres.2020.113337

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In humans, there is an endogenous, near 24-h (i.e., circadian) variation in mood with the best mood occurring during the circadian day and the worst mood occurring during the circadian night. Only positive affect, and not negative affect, has been shown to contribute to this circadian rhythm. We discovered a sharp circadian peak in negative affect during the circadian night coincident with a circadian trough in positive affect. These findings may help explain the association of depression with insomnia, the increased risk of suicide with nocturnal wakefulness, and the correlation between circadian misalignment and symptom severity in Major Depressive Disorder.

引用

页数：4

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