Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer

被引：26
|
作者：
Yang, Qingfan [1 ,2 ,3 ,4 ,5 ]
Gao, Jing [6 ]
Xu, Lixia [1 ,2 ,3 ,4 ]
Zeng, Zhirong [5 ]
Sung, Joseph J. Y. [1 ,2 ,3 ,4 ]
Yu, Jun [1 ,2 ,3 ,4 ]
机构：
[1] Chinese Univ Hong Kong, Inst Digest Dis, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, State Key Lab Digest Dis, Shatin, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China
[5] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 510275, Guangdong, Peoples R China
[6] Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
来源：
BIOMARKERS | 2013年 / 18卷 / 08期
基金：
中国国家自然科学基金;
关键词：
BCL6B; biomarker; gastric cancer; plasma DNA; promoter methylation; CPG ISLAND HYPERMETHYLATION; CELL-FREE DNA; BREAST-CANCER; SERUM DNA; METHYLATION; TUMOR; ANTIGEN;
D O I：
10.3109/1354750X.2013.853839
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We previously showed that BCL6B acts as a tumor suppressor in gastric cancer and up to 66% gastric cancer patients have promoter hypermethylation in tumor tissues. We aimed to evaluate the feasibility of detecting BCL6B methylation in plasma DNA as a potential biomarker for gastric cancer. Hypermethylation of the CpG islands in BCL6B promoter was detected in 42.5% (17/40) plasma DNA samples from gastric cancer patients, while no methylation was found in the plasma DNA of healthy controls (p<0.001). BCL6B methylation may serve as a novel potential non-invasive plasma biomarker for the detection of gastric cancer.
引用
收藏
页码：721 / 725
页数：5
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