In view of the problems existing in the filled wall system of the frame structure at present and combining with the technical requirements of the prefabricated building pushed by the state, this paper puts forward a kind of prefabricated infilled wall system with hollow thermal insulation. The main research contents include the structural design of the prefabricated infilled wall, the connection design between the infilled wall and frame beam and column, and the construction technology research of the prefabricated infilled wall system, which makes the fabricated infilled wall system studied have good insulation, heat insulation and sound insulation performance, as well as good seismic performance, thus possessing applicable value in engineering.