Metal free amination of 2-chloroazoles in aqueous medium

被引：21
|
作者：
Kumar, R. Uday [1 ]
Reddy, K. Harsha Vardhan [1 ]
Kumar, B. S. P. Anil [1 ]
Satish, G. [1 ]
Reddy, V. Prakash [1 ]
Nageswar, Y. V. D. [1 ]
机构：
[1] Indian Inst Chem Technol, MCP Div, Hyderabad 500607, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 06期
关键词：
Copper on chitosan; Recyclability; Boronic acids; 1,2,3-Triazoles; Click reaction; CATALYZED DIRECT AMINATION; C-H; COPPER; BENZOXAZOLES; WATER; AZOLES; DERIVATIVES; FORMAMIDES; ARYLATION; AMINES;
D O I：
10.1016/j.tetlet.2015.12.084
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A green approach for the synthesis of 2-amino azoles by the reaction of 2-chloro azoles with various types of amines using water as an environment friendly solvent at room temperature has been developed. The significant features of this methodology are short reaction time and easy product separation. This approach provides various biologically active compounds in good to excellent yields without adding any catalyst, ligand, or base. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：637 / 640
页数：4
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