Parallel synthesis of substituted imidazoles from 1,2-aminoalcohols

被引：57
|
作者：
Bleicher, KH
Gerber, F
Wüthrich, Y
Alanine, A
Capretta, A [1 ]
机构：
[1] Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada
[2] Hoffmann La Roche Ag, CH-4070 Basel, Switzerland
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 43期
基金：
加拿大自然科学与工程研究理事会;
关键词：
D O I：
10.1016/S0040-4039(02)01839-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Substituted imidazoles can be prepared efficiently from cyclic or acyclic 1,2-aminoalcohols via a four-step procedure involving acylation of the amine, oxidation of the alcohol, imine formation and cyclization. Examples are presented and the methodology is applied in the generation of a library of compounds containing a fused imidazole-azepine motif. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7687 / 7690
页数：4
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