Antifibrotic efficacy of a TGF-β kinase inhibitor on early-onset and end-stage of fibrosis in precision-cut human liver slices

被引:0
|
作者
Luangmonkong, Theerut [1 ,2 ]
Suriguga, Suriguga [1 ]
Bigaeva, Emilia [1 ]
Oosterhuis, Dorenda [1 ]
de Jong, Koert P. [3 ]
Schuppan, Detlef [4 ,5 ,6 ]
Mutsaers, Henricus A. [1 ]
Olinga, Peter [1 ]
机构
[1] Univ Groningen, Pharmaceut Technol & Biopharm, Groningen, Netherlands
[2] Mahidol Univ, Pharm, Bangkok 10700, Thailand
[3] Univ Med Ctr Groningen, Hepatopancreatobiliary Surg & Liver Transplant, NL-9713 AV Groningen, Netherlands
[4] Johannes Gutenberg Univ Mainz, Med Ctr, Translat Immunol, Med, D-55122 Mainz, Germany
[5] Johannes Gutenberg Univ Mainz, Med Ctr, Res Ctr Immunotherapy, D-55122 Mainz, Germany
[6] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Gastroenterol, Boston, MA 02215 USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
1434
引用
收藏
页码:909A / 910A
页数:2
相关论文
共 23 条
  • [1] Human precision-cut liver slices as a model to test antifibrotic drugs in the early onset of liver fibrosis
    Westra, Inge M.
    Mutsaers, Henricus A. M.
    Luangmonkong, Theerut
    Hadi, Mackenzie
    Oosterhuis, Dorenda
    de Jong, Koert P.
    Groothuis, Geny M. M.
    Olinga, Peter
    TOXICOLOGY IN VITRO, 2016, 35 : 77 - 85
  • [2] Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs
    Westra, Inge M.
    Oosterhuis, Dorenda
    Groothuis, Geny M. M.
    Olinga, Peter
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2014, 274 (02) : 328 - 338
  • [3] ANTIFIBROTIC EFFICACY OF TGF-BETA RECEPTOR ANTAGONIST IN PRECISION-CUT HUMAN AND RAT LIVER SLICES
    Luangmonkong, T.
    Mutsaers, R.
    Oosterhuis, D.
    Olinga, P.
    JOURNAL OF HEPATOLOGY, 2015, 62 : S477 - S478
  • [4] Human Precision-Cut Tissue Slices as a Tool to Study Fibrosis and the Efficacy of Antifibrotic Compounds
    Mutsaers, Henricus
    Westra, Inge
    Stribos, Isabel
    Oosterhuis, Dorenda
    Olinga, Peter
    FASEB JOURNAL, 2015, 29
  • [5] DISSECTING THE MOLECULAR ANTIFIBROTIC EFFECT OF THE TGF-BETA(I) RECEPTOR KINASE INHIBITOR GALUNISERTIB IN PRECISION-CUT LIVER SLICES
    Luangmonkong, T.
    Suriguga, S.
    Bigaeva, E.
    Oosterhuis, D.
    de Jong, K.
    Schuppan, D.
    Mutsaers, H.
    Olinga, P.
    JOURNAL OF HEPATOLOGY, 2016, 64 : S713 - S714
  • [6] Precision-cut rat, mouse, and human intestinal slices as novel models for the early-onset of intestinal fibrosis
    Pham, Bao Tung
    van Haaften, Wouter Tobias
    Oosterhuis, Dorenda
    Nieken, Judith
    de Graaf, Inge Anne Maria
    Olinga, Peter
    PHYSIOLOGICAL REPORTS, 2015, 3 (04):
  • [7] The Effect Of Anti-Fibrotic Drugs On The Early Onset Of Liver Fibrosis In Human Precision-Cut Liver Slices
    Westra, Inge M.
    Oosterhuis, Dorenda
    Groothuis, Geny M.
    Olinga, Peter
    HEPATOLOGY, 2013, 58 : 599A - 599A
  • [8] Precision-cut liver slices as an ex vivo model to evaluate antifibrotic therapies for liver fibrosis and cirrhosis
    Wang, Yongtao
    Leaker, Ben
    Qiao, Guoliang
    Sojoodi, Mozhdeh
    Eissa, Ibrahim Ragab
    Epstein, Eliana T.
    Eddy, Jonathan
    Dimowo, Oizoshimoshiofu
    Lauer, Georg M.
    Qadan, Motaz
    Lanuti, Michael
    Chung, Raymond T.
    Fuchs, Bryan C.
    Tanabe, Kenneth K.
    HEPATOLOGY COMMUNICATIONS, 2024, 8 (11)
  • [9] A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision-Cut Liver Slices
    Paish, Hannah L.
    Reed, Lee H.
    Brown, Helen
    Bryan, Mark C.
    Govaere, Olivier
    Leslie, Jack
    Barksby, Ben S.
    Macia, Marina Garcia
    Watson, Abigail
    Xu, Xin
    Zaki, Marco Y. W.
    Greaves, Laura
    Whitehall, Julia
    French, Jeremy
    White, Steven A.
    Manas, Derek M.
    Robinson, Stuart M.
    Spoletini, Gabriele
    Griffiths, Clive
    Mann, Derek A.
    Borthwick, Lee A.
    Drinnan, Michael J.
    Mann, Jelena
    Oakley, Fiona
    HEPATOLOGY, 2019, 70 (04) : 1377 - 1391
  • [10] Rat Precision-Cut Liver Slices as an In Vitro Model for the Early Onset of Liver Fibrosis to Test Anti-Fibrotic Drugs
    Westra, Inge M.
    Groothuis, Geny M.
    Olinga, Peter
    GASTROENTEROLOGY, 2011, 140 (05) : S981 - S981