Targeting signaling pathways in multiple myeloma

被引：1

作者：

Federica, Cavallo ^{[1
]}

Antonio, Palumbo

Guido, Tricot

Mario, Boccadoro

机构：

[1] Univ Turin, Div Ematol, Turin, Italy

[2] Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA

来源：

CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2006年 / 7卷 / 06期

关键词：

D O I：

10.2174/138920106779116883

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multiple mycloma (MM) is an incurable malignancy of terminally differentiated B-cells accounting for approximately 1 to 2% of all human cancers. The development of MM is believed to be a multistep transformation process that leads to progressive accumulation of genetic alterations. The interaction between MM and bone marrow (BM) microenviroment triggers multiple proliferative and antiapoptotic signaling pathways. Here we discuss the current understanding of signaling pathways, and their potential implication in targeted therapies in MM.

引用

页码：407 / 413

页数：7

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