An intramolecular antiparallel G-quadruplex formed by human telomere RNA

被引：43
|
作者：
Xiao, Chao-Da [1 ,3 ]
Shibata, Tomokazu [2 ]
Yamamoto, Yasuhiko [2 ]
Xu, Yan [1 ]
机构：
[1] Univ Miyazaki, Fac Med, Med Sci, 5200 Kihara, Miyazaki 8891692, Japan
[2] Univ Tsukuba, Dept Chem, Tsukuba, Ibaraki 3058571, Japan
[3] Guizhou Med Univ, Sch Pharmaceut Sci, State Key Lab Funct & Applicat Med Plants, Guian New Dist 550025, Guizhou, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 32期
关键词：
TERRA;
D O I：
10.1039/c8cc01427b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Until now, RNA G-quadruplexes were believed to only adopt a parallel G-quadruplex structure. In this study, we describe the first observation of an antiparallel RNA G-quadruplex formed by human telomere RNA. This newly described topology is of great interest as it shows that RNA G-quadruplexes can also be polymorphic and adopt structures that are different from the parallel configuration.
引用
收藏
页码：3944 / 3946
页数：3
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