Fragment-based drug discovery takes a virtual turn

被引：20

作者：

Pellecchia, Maurizio ^{[1
,2
]}

机构：

[1] Med Chem & Struct Biol Canc Ctr, La Jolla, CA USA

[2] Ctr Infect Dis, Burnham Inst Med Res, La Jolla, CA USA

来源：

NATURE CHEMICAL BIOLOGY | 2009年 / 5卷 / 05期

关键词：

D O I：

10.1038/nchembio0509-274

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the realm of modern drug discovery technologies, fragment-based approaches and virtual ligand screening are emerging alternative approaches to high-throughput screening (HTS). For as simple as it sounds, a hybrid approach in which fragments are discovered first in silico may be an unbeatable route to hit identification for some drug targets.

引用

页码：274 / 275

页数：3

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