Regioexhaustive Functionalization of the Carbocyclic Core of Isoquinoline: Concise Synthesis of Oxoaporphine Core and Ellipticine

被引：6

作者：

Horvath, Daniel Vajk ^{[1
]}

Domonyi, Frigyes ^{[1
]}

Palko, Roberta ^{[1
]}

Lomoschitz, Andrea ^{[1
]}

Soos, Tibor ^{[1
]}

机构：

[1] Hungarian Acad Sci, Inst Organ Chem, Res Ctr Nat Sci, Magyar Tudosok Korutja 2, H-1117 Budapest, Hungary

来源：

SYNTHESIS-STUTTGART | 2018年 / 50卷 / 11期

关键词：

isoquinoline; regioexhaustive; cross-coupling; heterocycles; fused-ring systems; ellipticine; CATALYZED ANNULATION; APORPHINE ALKALOIDS; DERIVATIVES; ACID; HETEROCYCLES; QUINOLINE; ALKYNES;

D O I：

10.1055/s-0037-1609153

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and versatile strategy has been developed for the functionalization of the carbocyclic core of the isoquinoline. This regioexhaustive approach employs electrophilic halogenation as a toolbox methodology and delivers highly decorated intermediates that can be further elaborated toward medicinally relevant building blocks or natural products.

引用

页码：2181 / 2190

页数：10

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