Nano-engineering block copolymer aggregates for drug delivery

被引：1169
|
作者：
Allen, C
Maysinger, D
Eisenberg, A
机构：
[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
[2] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H3G 1Y6, Canada
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 1999年 / 16卷 / 1-4期
基金：
加拿大自然科学与工程研究理事会;
关键词：
block copolymer micelles; hydrophobic drugs; morphology of micelles;
D O I：
10.1016/S0927-7765(99)00058-2
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
This review describes the properties of block copolymer micelles which influence their efficiency as drug delivery vehicles for hydrophobic drugs. The key performance related properties wt discuss are loading capacity, release kinetics, circulation time, biodistribution, size, size distribution and stability. Each of the properties is discussed in detail with specific attention given to the way in which they may be changed or controlled, the aim being to allow the reader to tailor-make block copolymer micelles for a particular application. In addition, the last section of the review focuses on the morphology of the micelles as another performance related property which, to this point, remains unexplored in this connection. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：3 / 27
页数：25
相关论文
共 50 条
  • [1] Nano-engineering block copolymer aggregates for drug delivery
    Allen, Christine
    Maysinger, Dusica
    Eisenberg, Adi
    Colloids and Surfaces B: Biointerfaces, 1999, 16 (01): : 3 - 27
  • [2] Drug delivery vehicles on a nano-engineering perspective
    Felice, Betiana
    Prabhakaran, Molamma P.
    Rodriguez, Andrea P.
    Ramakrishna, Seeram
    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2014, 41 : 178 - 195
  • [3] Nano-Engineering of Concrete
    Ulm, Franz-Josef
    ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING, 2012, 37 (02): : 481 - 488
  • [4] Nano-engineering pollination
    Lew, Roger R.
    NEW PHYTOLOGIST, 2018, 220 (01) : 8 - 9
  • [5] Nano-Engineering of Concrete
    Franz-Josef Ulm
    Arabian Journal for Science and Engineering, 2012, 37 : 481 - 488
  • [6] Experimental Mechanics in Nano-engineering
    Sciammarella, Cesar A.
    Sciammarella, Federico M.
    Lamberti, Luciano
    RECENT ADVANCES IN MECHANICS, 2011, : 275 - 312
  • [7] Nano-engineering crystal arrays
    Hadlington, S
    CHEMISTRY WORLD, 2004, 1 (06): : 7 - 7
  • [8] Drug governs the morphology of polyalkylated block copolymer aggregates
    Le Devedec, F.
    Her, S.
    Vogtt, K.
    Won, A.
    Li, X.
    Beaucage, G.
    Yip, C.
    Allen, C.
    NANOSCALE, 2017, 9 (07) : 2417 - 2423
  • [9] Block copolymer micelles as drug delivery systems
    Kwon, GS
    ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (02) : 167 - 167
  • [10] Towards scalable nano-engineering of graphene
    A. J. Martínez-Galera
    I. Brihuega
    A. Gutiérrez-Rubio
    T. Stauber
    J. M. Gómez-Rodríguez
    Scientific Reports, 4
12345