Activity of Heme Synthesis Enzymes in the Bone Marrow and Liver of August and Wistar Rats During the Neonatal Period and After Acute Postnatal Hypoxia

被引：1

作者：

Kolesnikov, S. I. ^{[1
,4
]}

Popova, A. S. ^{[2
]}

Krupitskaya, L. I. ^{[3
]}

Sinitskii, A. I. ^{[3
]}

Kolesnikova, L. I. ^{[1
]}

机构：

[1] Res Ctr Problems Family Hlth & Human Reprod, Irkutsk, Russia

[2] Municipal Clin Hosp 6, Chelyabinsk, Russia

[3] South Ural State Med Univ, Minist Hlth Russian Federat, Chelyabinsk, Russia

[4] Moscow MV Lomonosov State Univ, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 160卷 / 02期

关键词：

heme synthesis enzymes; acute hypoxia; neonatal period; August and Wistar rats; SYNTHETASE;

D O I：

10.1007/s10517-015-3125-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Activity of heme synthesis enzymes in newborn August and Wistar rats was studied after acute hypoxic hypoxia. Daily production of erythrocytes and activities of aminolevulinate synthase, aminolevulinate dehydratase, and heme synthetase were measured in the bone marrow (15-30 min after birth and on days 1 and 3 of life) and liver (day 3 after birth). Hypoxia was followed by a decrease in activity of heme synthesis enzymes in the liver (especially in August rats) and reduction of the daily erythrocyte production (especially in Wistar rats). Our results suggest that the response of heme synthesis enzymes to hypoxic exposure in newborn rats is genetically determined. The observed changes are more pronounced in Wistar rats.

引用

页码：193 / 195

页数：3

共 32 条

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S. I. Kolesnikov
A. S. Popova
L. I. Krupitskaya
A. I. Sinitskii
L. I. Kolesnikova
Bulletin of Experimental Biology and Medicine, 2015, 160 : 193 - 195
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[7] Effect of semax heptapeptide on rat heart activity during acute hypobaric hypoxia in the early postnatal period
M. V. Maslova
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[8] Effect of Semax heptapeptide on rat heart activity during acute hypobaric hypoxia in the early postnatal period
Maslova, MV
Krushinskaya, YV
Maklakova, AS
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Ashmarin, IP
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1999, 128 (08) : 797 - 799
[9] Cardioprotective Activity of Pharmacological Agents Affecting NO Production and Bioavailability in the Early Postnatal Period after Intrauterine Hypoxia in Rats
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Belenichev, Igor
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BIOMEDICINES, 2023, 11 (10)
[10] TECHNIQUE FOR MEASURING ACTIVITY OF DRUG-METABOLIZING-ENZYMES IN MICE AND RATS INVIVO DURING EARLY POSTNATAL-PERIOD
HAUSER, R
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