Multiple age-associated mitochondrial DNA deletions in mouse brain

被引：0
|
作者：
Kim, JS
Kim, MJ
Kwon, IS
Song, ES
机构：
[1] SOOKMYUNG WOMENS UNIV,DEPT BIOL,SEOUL 140742,SOUTH KOREA
[2] NATL INST AGR SCI & TECHNOL,DIV MOL GENET,SUWON 441707,SOUTH KOREA
来源：
JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1997年 / 30卷 / 01期
关键词：
aging; brain; mitochondrial DNA; multiple deletion;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Age-dependent deletion of mitochondrial DNA (mtDNA) was detected in mouse brain using PCR method. The size of the deleted fragment was 0.5 kb, 0.9 kb. 1.7 kb and 4.3 kb in the region between cytochrome b gene and ATPase 6 gene. The deleted fragment was increased gradually from 3-month to 22-month. Direct repeat sequence flanking the deletion in 0.5 kb PCR product was TAAT.
引用
收藏
页码：33 / 36
页数：4
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