Mechanisms and dynamics of antioxidant action of ubiquinol

被引：0
|
作者：
Niki, E [1 ]
机构：
[1] UNIV TOKYO,ADV SCI & TECHNOL RES CTR,MEGURO KU,TOKYO 153,JAPAN
来源：
MOLECULAR ASPECTS OF MEDICINE | 1997年 / 18卷
关键词：
ubiquinol; coenzyme Q; vitamin E; antioxidant; lipid peroxidation;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mechanisms and dynamics of antioxidant action of ubiquinol have been studied. Ubiquinol scavenges peroxyl radical faster than alpha-tocopherol. However, it is autooxidized rapidly to give hydroperoxyl radical and/or superoxide and hence its antioxidant potency is smaller than that of alpha-tocopherol. The side chain of ubiquinol reduces the mobility between the membranes. It was concluded that ubiquinol acts as a potent antioxidant in combination with alpha-tocopherol. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：S63 / S70
页数：8
相关论文
共 50 条
  • [1] Dynamics of antioxidant action of ubiquinol: a reappraisal
    Shi, HL
    Noguchi, N
    Niki, E
    [J]. BIOFACTORS, 1999, 9 (2-4) : 141 - 148
  • [2] Mechanisms of antioxidant action
    Cadenas, E
    [J]. FREE RADICALS, OXIDATIVE STRESS, AND ANTIOXIDANTS: PATHOLOGICAL AND PHYSIOLOGICAL SIGNIFICANCE, 1998, 296 : 237 - 251
  • [3] The Study of Neuroprotective Mechanisms of the Ubiquinol Action in Experimental Focal Ischemia
    T. N. Fedorova
    V. S. Gusakov
    A. A. Devyatov
    O. A. Muzichuk
    A. V. Lopachev
    M. A. Belousova
    S. L. Stvolinskii
    O. V. Povarova
    M. V. Gulyaev
    O. S. Medvedev
    V. A. Tutelyan
    [J]. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 2020, 14 : 329 - 334
  • [4] The Study of Neuroprotective Mechanisms of the Ubiquinol Action in Experimental Focal Ischemia
    Fedorova, T. N.
    Gusakov, V. S.
    Devyatov, A. A.
    Muzichuk, O. A.
    Lopachev, A., V
    Belousova, M. A.
    Stvolinskii, S. L.
    Povarova, O., V
    Gulyaev, M., V
    Medvedev, O. S.
    Tutelyan, V. A.
    [J]. BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY, 2020, 14 (04) : 329 - 334
  • [5] ANTIOXIDANT ACTION OF UBIQUINOL HOMOLOGS WITH DIFFERENT ISOPRENOID CHAIN-LENGTH IN BIOMEMBRANES
    KAGAN, VE
    SERBINOVA, EA
    KOYNOVA, GM
    KITANOVA, SA
    TYURIN, VA
    STOYTCHEV, TS
    QUINN, PJ
    PACKER, L
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1990, 9 (02) : 117 - 126
  • [6] MECHANISMS OF ANTIOXIDANT ACTION - THE ANTIOXIDANT ACTIVITY OF NITRONES IN POLYPROPYLENE
    CHAKRABORTY, KB
    SCOTT, G
    YAGHMOUR, H
    [J]. JOURNAL OF APPLIED POLYMER SCIENCE, 1985, 30 (08) : 3267 - 3281
  • [7] MECHANISMS OF ANTIOXIDANT ACTION - CUPRIC STEARATE AS A CATALYTIC ANTIOXIDANT
    BAGHERI, R
    CHAKRABORTY, KB
    SCOTT, G
    [J]. POLYMER DEGRADATION AND STABILITY, 1985, 11 (01) : 1 - 7
  • [8] MECHANISMS OF ANTIOXIDANT ACTION - THE BEHAVIOR OF A BOUND ANTIOXIDANT AS AN ANTIOZONANT
    KATBAB, AA
    SCOTT, G
    [J]. POLYMER DEGRADATION AND STABILITY, 1981, 3 (03) : 221 - 227
  • [9] Mechanisms of action of the antioxidant lycopene in cancer
    Levy, J
    Danilenko, M
    Karas, M
    Amir, H
    Nahum, A
    Giat, Y
    Sharoni, Y
    [J]. NATURAL ANTIOXIDANTS AND ANTICARCINOGENS IN NUTRITION, HEALTH AND DISEASE, 1999, (240): : 377 - 384
  • [10] Molecular and biological mechanisms of antioxidant action
    Frei, B
    [J]. FASEB JOURNAL, 1999, 13 (09): : 963 - 964
12345