Association between marijuana use and adverse obstetrical and neonatal outcomes

被引:88
|
作者
Warshak, C. R. [1 ]
Regan, J. [1 ]
Moore, B. [1 ]
Magner, K. [2 ]
Kritzer, S. [3 ]
Van Hook, J. [1 ]
机构
[1] Univ Cincinnati, Coll Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, Cincinnati, OH 45267 USA
[2] Christ Hosp, Dept Obstet & Gynecol, Cincinnati, OH 45219 USA
[3] Northwestern Univ, Feinberg Sch Med, Dept Obstet & Gynecol, Chicago, IL 60611 USA
关键词
SMOKING;
D O I
10.1038/jp.2015.120
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: To evaluate associations between marijuana exposure and adverse outcomes excluding women with polysubstance abuse and stratifying for concurrent maternal tobacco use. STUDY DESIGN: We performed a retrospective cohort study evaluating various obstetrical and neonatal outcomes including: preterm delivery, pre-eclampsia, gestational diabetes, cesarean delivery, fetal growth restriction, a composite which included stillbirth or neonatal intensive care unit admission, and perinatal mortality. We stratified study groups according to the maternal tobacco use and performed a logistic regression analysis. RESULTS: We included 6468 women, 6107 nonusers and 361 marijuana users. After adjustment for maternal age, race, parity, body mass index and no prenatal care, we found higher rates of small for gestational age (aOR 1.30 (95% CI 1.03 to 1.62)) and neonatal intensive care unit admission (aOR 1.54 (1.14 to 2.07)) in women who were not tobacco users. Other obstetrical outcomes including preterm delivery and fetal anomalies were not increased with maternal marijuana use. CONCLUSION: Maternal marijuana use does not increase the risk of adverse obstetrical outcomes or fetal anomalies, but does increase the risk for small for gestational age and neonatal intensive care unit admission.
引用
收藏
页码:991 / 995
页数:5
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