Ectopic fat: the true culprit linking obesity and cardiovascular disease?

被引：51

作者：

Morelli, Mariangela ^{[1
,2
]}

Gaggini, Melania ^{[1
,3
]}

Daniele, Giuseppe ^{[4
,5
]}

Marraccini, Paolo ^{[1
]}

Sicari, Rosa ^{[1
]}

Gastaldelli, Amalia ^{[1
,5
]}

机构：

[1] CNR, Inst Clin Physiol, I-56100 Pisa, Italy

[2] Univ Milan, Milan, Italy

[3] Univ Pisa, Dept Surg, I-56100 Pisa, Italy

[4] Univ Pisa, Dept Endocrinol & Metab, I-56100 Pisa, Italy

[5] Univ Texas Hlth Sci Ctr San Antonio, Div Diabet, San Antonio, TX USA

来源：

THROMBOSIS AND HAEMOSTASIS | 2013年 / 110卷 / 04期

关键词：

SUBCUTANEOUS ADIPOSE-TISSUE; TYPE-2; DIABETES-MELLITUS; CORONARY-HEART-DISEASE; CARDIOMETABOLIC RISK-FACTORS; VISCERAL ABDOMINAL FAT; NECROSIS-FACTOR-ALPHA; LOW-CALORIE DIET; INSULIN-RESISTANCE; METABOLICALLY HEALTHY; BARIATRIC SURGERY;

D O I：

10.1160/TH13-04-0285

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is a major risk factor for cardiovascular disease and its complications. However, not all fat depots share the same characteristics. Recent studies have found that ectopic rather than subcutaneous fat accumulation is associated with increased cardiometabolic risk. However, ectopic fat accumulation can be seen initially as a protective mechanism against lipotoxicity. Subsequently the adipose tissue becomes dysfunctional, thus inducing systemic metabolic alterations (through release of cytokines) or specific organ dysfunctions. The purpose of this review is to summarise the current available data on the impact of excess adiposity vs ectopic fat in the development of cardiometabolic diseases.

引用

页码：651 / 660

页数：10

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