Alzheimer's disease: the amyloid hypothesis on trial

被引：64
|
作者：
Harrison, Judith R. [1 ]
Owen, Michael J. [1 ]
机构：
[1] Cardiff Univ, Sch Med, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Maindy Rd, Cardiff CF24 4HQ, S Glam, Wales
来源：
BRITISH JOURNAL OF PSYCHIATRY | 2016年 / 208卷 / 01期
基金：
英国医学研究理事会;
关键词：
HYPOTHETICAL MODEL; CLINICAL-TRIALS; ASSOCIATION;
D O I：
10.1192/bjp.bp.115.167569
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The pathogenesis of Alzheimer's disease is complex. The amyloid hypothesis has directed research efforts for many years, but it has recently been questioned after failed drug trials. Here, we review the evidence for and against and suggest that it might be premature to abandon the amyloid hypothesis.
引用
收藏
页码：1 / 3
页数：3
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