A novel translocation, t(9;21)(q13;q22) rearranging the RUNX1 gene in acute myelomonocytic leukemia

被引：4
|
作者：
Paulien, S [1 ]
Maarek, O [1 ]
Daniel, MT [1 ]
Berger, R [1 ]
机构：
[1] Hop St Louis, Lab Cent Hematol, F-75010 Paris, France
来源：
ANNALES DE GENETIQUE | 2002年 / 45卷 / 02期
关键词：
AML-M4; RUNX1; gene; translocation t(9; 21);
D O I：
10.1016/S0003-3995(02)01113-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A novel translocation t(9;21)(q13;q22) associated with trisomy 4 has been detected in a patient with acute myelomonocytic leukemia (AML,M4) in relapse. The chromosomal translocation results in rearrangement of the RUNX1 gene at 21q22. The DNA sequence rearranged on chromosome 9 remains unidentified. The diversity of the partners involved in translocations implicating RUNX1 suggests that the functional consequences of the abnormality are more due to the truncation of RUNX1 than to the identity of its partner in the rearrangement. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：67 / 69
页数：3
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