Biological functions of m6A methyltransferases

被引：42

作者：

Gu, Jianzhong ^{[1
,2
]}

Zhan, Yu ^{[2
]}

Zhuo, Lvjia ^{[1
,3
]}

Zhang, Qin ^{[1
,3
]}

Li, Guohua ^{[1
,3
]}

Li, Qiujie ^{[1
,3
]}

Qi, Shasha ^{[1
,3
]}

Zhu, Jinyu ^{[1
,3
]}

Lv, Qun ^{[4
]}

Shen, Yingying ^{[2
]}

Guo, Yong ^{[2
]}

Liu, Shuiping ^{[1
,3
]}

Xie, Tian ^{[1
,3
]}

Sui, Xinbing ^{[1
,3
]}

机构：

[1] Hangzhou Normal Univ, Sch Med, Coll Pharm, Hangzhou 311121, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Oncol, 54 Youdian Rd, Hangzhou 310006, Zhejiang, Peoples R China

[3] Hangzhou Normal Univ, Collaborat Innovat Ctr Tradit Chinese Med Zhejian, Engn Lab Dev & Applicat Tradit Chinese Med, Key Lab Elemene Class Anticanc Chinese Med, Hangzhou 311121, Zhejiang, Peoples R China

[4] Hangzhou Normal Univ, Affiliated Hosp, Sch Med, Dept Resp Med, Hangzhou 310015, Zhejiang, Peoples R China

来源：

CELL AND BIOSCIENCE | 2021年 / 11卷 / 01期

基金：

中国国家自然科学基金;

关键词：

M(6)A methyltransferase; Growth and development; Metabolism; Infection and immunity; Tumour progression;

D O I：

10.1186/s13578-020-00513-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

M(6)A methyltransferases, acting as a writer in N6-methyladenosine, have attracted wide attention due to their dynamic regulation of life processes. In this review, we first briefly introduce the individual components of m(6)A methyltransferases and explain their close connections to each other. Then, we concentrate on the extensive biological functions of m(6)A methyltransferases, which include cell growth, nerve development, osteogenic differentiation, metabolism, cardiovascular system homeostasis, infection and immunity, and tumour progression. We summarize the currently unresolved problems in this research field and propose expectations for m(6)A methyltransferases as novel targets for preventive and curative strategies for disease treatment in the future.

引用

页数：16

共 50 条

[1] Biological functions of m6A methyltransferases
Jianzhong Gu
Yu Zhan
Lvjia Zhuo
Qin Zhang
Guohua Li
Qiujie Li
Shasha Qi
Jinyu Zhu
Qun Lv
Yingying Shen
Yong Guo
Shuiping Liu
Tian Xie
Xinbing Sui
Cell & Bioscience, 11
[2] The role of m6A modification in the biological functions and diseases
Jiang, Xiulin
Liu, Baiyang
Nie, Zhi
Duan, Lincan
Xiong, Qiuxia
Jin, Zhixian
Yang, Cuiping
Chen, Yongbin
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 6 (01)
[3] The role of m6A modification in the biological functions and diseases
Xiulin Jiang
Baiyang Liu
Zhi Nie
Lincan Duan
Qiuxia Xiong
Zhixian Jin
Cuiping Yang
Yongbin Chen
Signal Transduction and Targeted Therapy, 6
[4] Principles, functions, and biological implications of m6A in plants
Song, Peizhe
Cai, Zhihe
Jia, Guifang
RNA, 2024, 30 (05) : 491 - 499
[5] The Functions of Fiona/Mett10/Mettl16 Family of m6A Methyltransferases
Gong, Juan
Huang, Wu-Qiang
Rong, Yi-Kang
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2023, 50 (11) : 2513 - 2522
[6] Recent Advances of m6A Demethylases Inhibitors and Their Biological Functions in Human Diseases
You, Yazhen
Fu, Yundong
Huang, Mingjie
Shen, Dandan
Zhao, Bing
Liu, Hongmin
Zheng, Yichao
Huang, Lihua
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (10)
[7] The detection and functions of RNA modification m6A based on m6A writers and erasers
Zhang, Wei
Qian, Yang
Jia, Guifang
JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 297 (02)
[8] RNA m6A Modification in Immunocytes and DNA Repair: The Biological Functions and Prospects in Clinical Application
Zhou, Mingjie
Liu, Wei
Zhang, Jieyan
Sun, Nan
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
[9] RNA Binding by the m6A Methyltransferases METTL16 and METTL3
Mansfield, Kyle D.
BIOLOGY-BASEL, 2024, 13 (06):
[10] Versatile functions of RNA m6A machinery on chromatin
Song, Tanjing
Lv, Suli
Li, Neng
Zhao, Xuefeng
Ma, Xianyun
Yan, Yingying
Wang, Weixia
Sun, Lidong
JOURNAL OF MOLECULAR CELL BIOLOGY, 2022, 14 (03)

← 1 2 3 4 5 →