Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach

被引：19
|
作者：
Samocha-Bonet, Dorit [1 ,2 ]
Debs, Sophie [1 ]
Greenfield, Jerry R. [1 ,2 ,3 ]
机构：
[1] Garvan Inst Med Res, Diabet & Metab Div, Sydney, NSW 2010, Australia
[2] Univ New South Wales, St Vincents Clin Sch, Fac Med, Sydney, NSW 2010, Australia
[3] St Vincents Hosp, Dept Endocrinol & Diabet Serv, Sydney, NSW 2010, Australia
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 06期
关键词：
LIFE-STYLE INTERVENTION; HEPATIC GLUCOSE-PRODUCTION; CATION TRANSPORTER 1; 10-YEAR FOLLOW-UP; WEIGHT-LOSS; INSULIN-RESISTANCE; GLYCEMIC RESPONSE; METFORMIN ALTERS; SKELETAL-MUSCLE; ASSOCIATION;
D O I：
10.1016/j.tem.2018.03.014
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Prediabetes affects approximately 40% of American adults. Randomized trials report that a proportion of individuals with prediabetes develop diabetes despite caloric restriction, physical activity, and/or when treated with metformin, the first-line medication for patients with type 2 diabetes mellitus (T2DM). Currently, there are no valid predictors of the effectiveness of these measures in determining who will and who will not progress to the T2DM state. Few studies have examined the clinical and phenotypic predictors of better and worse glycemic response to lifestyle interventions and metformin in prediabetes and diabetes. Further studies incorporating 'omic' approaches to discover novel markers of phenotypes and treatment effectiveness may pave the way to personalizing the treatment of prediabetes and diabetes.
引用
收藏
页码：370 / 379
页数：10
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