TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

被引：72

作者：

Wang, Chunmei ^{[1
]}

He, Yanlin ^{[1
]}

Xu, Pingwen ^{[1
]}

Yang, Yongjie ^{[1
]}

Saito, Kenji ^{[1
]}

Xia, Yan ^{[1
]}

Yan, Xiaofeng ^{[1
]}

Hinton, Antentor, Jr. ^{[1
]}

Yan, Chunling ^{[1
]}

Ding, Hongfang ^{[1
]}

Yu, Likai ^{[1
]}

Shu, Gang ^{[1
]}

Gupta, Rajat ^{[2
]}

Wu, Qi ^{[1
]}

Tong, Qingchun ^{[3
]}

Lagor, William R. ^{[2
]}

Flores, Elsa R. ^{[4
]}

Xu, Yong ^{[1
,5
]}

机构：

[1] Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, Houston, TX 77030 USA

[2] Baylor Coll Med, Mol Physiol & Biophys, Houston, TX 77030 USA

[3] Univ Texas Hlth Sci Ctr Houston, Brown Fdn, Inst Mol Med, Houston, TX 77030 USA

[4] H Lee Moffitt Canc Ctr & Res Inst, Dept Mol Oncol, Canc Biol & Evolut Program, Dept Cutaneous Oncol, Tampa, FL 33612 USA

[5] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

ESTROGEN-RECEPTOR-ALPHA; SEROTONIN 2C RECEPTORS; EARLY-ONSET OBESITY; BODY-WEIGHT; FOOD-INTAKE; BRAIN-STEM; PROOPIOMELANOCORTIN NEURONS; FRAMESHIFT MUTATION; NUCLEUS; MICE;

D O I：

10.1038/s41467-018-03796-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sexual dimorphism exists in energy balance, but the underlying mechanisms remain unclear. Here we show that the female mice have more pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus than males, and female POMC neurons display higher neural activities, compared to male counterparts. Strikingly, deletion of the transcription factor, TAp63, in POMC neurons confers "male-like" diet-induced obesity (DIO) in female mice associated with decreased POMC neural activities; but the same deletion does not affect male mice. Our results indicate that TAp63 in female POMC neurons contributes to the enhanced POMC neuron functions and resistance to obesity in females. Thus, TAp63 in POMC neurons is one key molecular driver for the sexual dimorphism in energy homeostasis.

引用

页数：11

共 13 条

[1] TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
Chunmei Wang
Yanlin He
Pingwen Xu
Yongjie Yang
Kenji Saito
Yan Xia
Xiaofeng Yan
Antentor Hinton Jr
Chunling Yan
Hongfang Ding
Likai Yu
Gang Shu
Rajat Gupta
Qi Wu
Qingchun Tong
William R. Lagor
Elsa R. Flores
Yong Xu
Nature Communications, 9
[2] TAp63 in Mature POMC Neurons Regulates Glucose and Energy Homeostasis
Wang, Chunmei
He, Yanlin
Xu, Pingwen
Yang, Yongjie
Xu, Yong
DIABETES, 2018, 67
[3] TAp63 tips the energy balance?
Darren J. Burgess
Nature Reviews Cancer, 2012, 12 : 736 - 737
[4] METABOLISM TAp63 tips the energy balance?
Burgess, Darren J.
NATURE REVIEWS CANCER, 2012, 12 (11) : 736 - 736
[5] Gabra 5 contributes to sexual dimorphism in POMC neural activity and glucose metabolism
Pei, Zhou
HORMONE RESEARCH IN PAEDIATRICS, 2019, 91 : 69 - 69
[6] Functions of TAp63 and p53 in restraining the development of metastatic cancer
E H Tan
J P Morton
P Timpson
P Tucci
G Melino
E R Flores
O J Sansom
K H Vousden
P A J Muller
Oncogene, 2014, 33 : 3325 - 3333
[7] Functions of TAp63 and p53 in restraining the development of metastatic cancer
Tan, E. H.
Morton, J. P.
Timpson, P.
Tucci, P.
Melino, G.
Flores, E. R.
Sansom, O. J.
Vousden, K. H.
Muller, P. A. J.
ONCOGENE, 2014, 33 (25) : 3325 - 3333
[8] ΔNp63α and TAp63α regulate transcription of genes with distinct biological functions in cancer and development
Wu, GJ
Nomoto, S
Hoque, MO
Dracheva, T
Osada, M
Lee, CCR
Dong, SM
Guo, ZM
Benoit, N
Cohen, Y
Rechthand, P
Califano, J
Moon, CS
Ratovitski, E
Jen, J
Sidransky, D
Trink, B
CANCER RESEARCH, 2003, 63 (10) : 2351 - 2357
[9] Central p62 contributes to peripheral energy metabolic balance and homeostasis via STAT3-POMC signalling
Yang, S.
Li, L.
Yang, G.
DIABETOLOGIA, 2023, 66 (SUPPL 1) : S271 - S271
[10] Sexual Dimorphism in Adipose-Hypothalamic Crosstalk and the Contribution of Aryl Hydrocarbon Receptor to Regulate Energy Homeostasis
Haque, Nazmul
Tischkau, Shelley A.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (14)

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