Neuroinflammation and Neuroprotective Strategies in Acute Ischaemic Stroke - from bench to bedside

被引：50

作者：

Shah, Imtiaz M. ^{[2
]}

Macrae, I. Mhairi ^{[3
]}

Di Napoli, Mario ^{[1
,4
]}

机构：

[1] SMDN Ctr Cardiovasc Med & Cerebrovasc Dis Prevent, Neurol Sect, I-67039 Sulmona, AQ, Italy

[2] Victoria Infirm, Mansionhouse Unit, Dept Med Elderly, Glasgow G41 3DX, Lanark, Scotland

[3] Univ Glasgow, Wellcome Surg Inst, Div Clin Neurosci, Glasgow G61 1QH, Lanark, Scotland

[4] San Camillo deLellis Gen Hosp, Neurol Serv, Rieti, Italy

来源：

CURRENT MOLECULAR MEDICINE | 2009年 / 9卷 / 03期

关键词：

Acute stroke; neuroinflammation; neuroprotection; cytokines; inflammatory mediators; oxidative stress; systemic inflammatory response; translational medicine; FOCAL CEREBRAL-ISCHEMIA; MONOCYTE-CHEMOATTRACTANT PROTEIN-1; NITRIC-OXIDE SYNTHASE; C-REACTIVE PROTEIN; NF-KAPPA-B; INTERLEUKIN-1 RECEPTOR ANTAGONIST; TUMOR-NECROSIS-FACTOR; INFLAMMATORY RESPONSE SYNDROME; CENTRAL-NERVOUS-SYSTEM; INDUCED NEUTROPHIL CHEMOATTRACTANT;

D O I：

10.2174/156652409787847236

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cerebrovascular disease is one of the commonest causes of disability and mortality worldwide. Over the past two decades, a tremendous amount of research has been undertaken into developing effective therapeutic strategies for the treatment of acute stroke. Unfortunately, many neuroprotective agents that have shown successful results in treating animal models of acute stroke have failed to translate into clinical treatments. Only tissue-plasminogen activator (t-PA) is currently licensed for use in the treatment of acute ischaemic stroke. One of the important pathophysiological mechanisms involved during the acute phase of stroke is neuroinflammation. This review article will discuss the molecular aspects of neuroinflammation in acute ischaemic stroke and potential therapeutic strategies as part of translational medicine research.

引用

页码：336 / 354

页数：19

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