Subtle cognitive dysfunction in adult onset myotonic dystrophy type 1 (DM1) and type 2 (DM2)

被引:52
|
作者
Gaul, C.
Schmidt, T.
Windisch, G.
Wieser, T.
Mueller, T.
Vielhaber, S.
Zierz, S.
Leplow, B.
机构
[1] Univ Halle Wittenberg, Dept Neurol, D-06097 Halle, Germany
[2] Univ Halle Wittenberg, Dept Clin Psychol & Psychotherapy, D-06097 Halle, Germany
[3] Otto Von Guericke Univ, Dept Neurol 2, Magdeburg, Germany
关键词
D O I
10.1212/01.wnl.0000225180.27833.c1
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors performed neuropsychological testing in 21 patients with myotonic dystrophy type 1 (DM1) and 21 with type 2 (DM2) and healthy controls. They detected no general cognitive deficit in either DM1 or DM2, but compared to controls, both groups of patients were inferior in tests of prefrontal functioning. Patient groups did not differ in any measure. Mood status was not related to neuropsychological performance. This is consistent with findings of executive dysfunction in both DM1 and DM2.
引用
收藏
页码:350 / 352
页数:3
相关论文
共 50 条
  • [1] The frequency of myotonic dystrophy type 2 (DM2) and type 1 (DM1) mutations in the population
    Suominen, T.
    Bachinski, L. L.
    Auvinen, S.
    Hackman, P.
    Angelini, C.
    Peltonen, L.
    Krahe, R.
    Udd, B.
    [J]. NEUROMUSCULAR DISORDERS, 2010, 20 (9-10) : 628 - 628
  • [2] Gastrointestinal (GI) symptoms in myotonic dystrophy type 1 and type 2 (DM1 and DM2)
    Hilbert, James E.
    Martens, William B.
    Smirnow, Alexis M.
    Moxley, Richard T., III
    [J]. ANNALS OF NEUROLOGY, 2008, 64 : S7 - S7
  • [3] Histopathological differences of myotonic dystrophy type 1 (DM1) and PROMM/DM2
    Vihola, A
    Bassez, G
    Meola, G
    Zhang, S
    Haapasalo, H
    Paetau, A
    Mancinelli, E
    Rouche, A
    Hogrel, JY
    Laforêt, P
    Maisonobe, T
    Pellissier, JF
    Krahe, R
    Eymard, B
    Udd, B
    [J]. NEUROLOGY, 2003, 60 (11) : 1854 - 1857
  • [4] Pattern of brain involvement myotonic dystrophy type 1 (DM1) versus type 2 (DM2)
    Angelini, Corrado
    Ferrati, Chiara
    Romeo, Vincenzo
    Ermani, Mario
    [J]. NEUROLOGY, 2008, 70 (11) : A306 - A306
  • [5] Analysis of MTMR1 expression and correlation with muscle pathological features in juvenile/adult onset myotonic dystrophy type 1 (DM1) and in myotonic dystrophy type 2 (DM2)
    Santoro, Massimo
    Modoni, Anna
    Masciullo, Marcella
    Gidaro, Teresa
    Broccolini, Aldobrando
    Ricci, Enzo
    Tonali, Pietro Attilio
    Silvestri, Gabriella
    [J]. EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2010, 89 (02) : 158 - 168
  • [6] Differences in distribution and type of myotonic discharges in genetically confirmed myotonic dystrophy type 1 (DM1) versus type 2 (DM2)
    Logigian, E
    Ciafaloni, E
    Quinn, C
    Dilek, N
    Moxley, R
    Thornton, C
    [J]. NEUROLOGY, 2006, 66 (05) : A320 - A320
  • [7] Myotonic dystrophy: Emerging mechanisms for DM1 and DM2
    Cho, Diane H.
    Tapscott, Stephen J.
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2007, 1772 (02): : 195 - 204
  • [8] Progressive frontal lobe impairment in myotonic dystrophy type 1 (DM1) and type 2 (DM2): A longitudinal study
    Meola, G
    Sansone, V
    Gandossini, S
    Milanese, SD
    Cattaneo, E
    Brescia, A
    Cotticelli, B
    Zanetti, O
    Calabria, M
    Cotelli, M
    Binetti, G
    [J]. NEUROLOGY, 2005, 64 (06) : A415 - A415
  • [9] Erectile dysfunction in myotonic dystrophy type 1 (DM1)
    Antonini, Giovanni
    Clemenzi, Alessandro
    Bucci, Elisabetta
    Morino, Stefania
    Garibaldi, Matteo
    Sepe-Monti, Micaela
    Giubilei, Franco
    Novelli, Giuseppe
    [J]. JOURNAL OF NEUROLOGY, 2009, 256 (04) : 657 - 659
  • [10] Erectile dysfunction in myotonic dystrophy type 1 (DM1)
    Giovanni Antonini
    Alessandro Clemenzi
    Elisabetta Bucci
    Stefania Morino
    Matteo Garibaldi
    Micaela Sepe-Monti
    Franco Giubilei
    Giuseppe Novelli
    [J]. Journal of Neurology, 2009, 256 : 657 - 659