Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond

被引：19
|
作者：
Nishibori, Masahiro [1 ]
Wake, Hidenori [1 ]
Morimatsu, Hiroshi [2 ]
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pharmacol, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan
[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Anesthesiol & Resuscitol, Okayama 7008558, Japan
来源：
CRITICAL CARE | 2018年 / 22卷
关键词：
Sepsis; Biomarker; Histidine-rich; glycoprotein; Diagnosis; SEPTIC SHOCK;
D O I：
10.1186/s13054-018-2127-5
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Sepsis remains a critical problem with high morbidity and mortality worldwide. One of the problems we have in critical care is the need to find a good biomarker of sepsis to determine the existence of bacterial infection and the severity of patients. This would enable us to start appropriate treatment at an earlier stage of the disease course. We propose that decreases in the plasma protein histidine-rich glycoprotein (HRG) is an excellent biomarker of sepsis compared with the current markers. Based on the novel pathophysiological roles of HRG in the cascade of events during sepsis, we also discuss the potential for supplemental therapy with purified HRG.
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond
    Masahiro Nishibori
    Hidenori Wake
    Hiroshi Morimatsu
    Critical Care, 22
  • [2] Histidine-rich glycoprotein as a prognostic biomarker for sepsis
    Kuroda, Kosuke
    Ishii, Kenzo
    Mihara, Yuko
    Kawanoue, Naoya
    Wake, Hidenori
    Mori, Shuji
    Yoshida, Michihiro
    Nishibori, Masahiro
    Morimatsu, Hiroshi
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [3] Histidine-rich glycoprotein as a prognostic biomarker for sepsis
    Kosuke Kuroda
    Kenzo Ishii
    Yuko Mihara
    Naoya Kawanoue
    Hidenori Wake
    Shuji Mori
    Michihiro Yoshida
    Masahiro Nishibori
    Hiroshi Morimatsu
    Scientific Reports, 11
  • [4] HISTIDINE-RICH GLYCOPROTEIN AS A NEW BIOMARKER FOR SEPSIS: COMPARISON TO PROCALCITONIN AND PRESEPSIN
    Kuroda, Kosuke
    Morimatsu, Hiroshi
    Wake, Hidenori
    Mori, Shiji
    Nishibori, Masahiro
    CRITICAL CARE MEDICINE, 2015, 43 (12)
  • [5] Histidine-Rich Glycoprotein as an Early Biomarker of Preeclampsia
    Bolin, Marie
    Akerud, Peter
    Hansson, Agneta
    Akerud, Helena
    AMERICAN JOURNAL OF HYPERTENSION, 2011, 24 (04) : 496 - 501
  • [6] HISTIDINE-RICH GLYCOPROTEIN AS A NOVEL BIOMARKER FOR SEPSIS: SUBGROUP ANALYSIS OF THE TIME-DEPENDENT CHANGE
    Kawanoue, Naoya
    Morimatsu, Hiroshi
    Kuroda, Kosuke
    Wake, Hidenori
    Mori, Shuji
    Nishibori, Masahiro
    ANESTHESIA AND ANALGESIA, 2018, 126 (04): : 164 - 164
  • [7] DECREASE IN HISTIDINE-RICH GLYCOPROTEIN AS A NOVEL PROGNOSTIC BIOMARKER FOR SEPSIS: A MULTICENTER PROSPECTIVE OBSERVATIONAL STUDY
    Kuroda, Kosuke
    Morimatsu, Hiroshi
    Kawanoue, Naoya
    Wake, Hidenori
    Mori, Shuji
    Nishibori, Masahiro
    ANESTHESIA AND ANALGESIA, 2018, 126 (04): : 150 - 150
  • [8] PLATELET HISTIDINE-RICH GLYCOPROTEIN
    LEUNG, LLK
    HARPEL, PC
    NACHMAN, RL
    METHODS IN ENZYMOLOGY, 1989, 169 : 268 - 276
  • [9] Decrease in Histidine-Rich Glycoprotein as a Novel Biomarker to Predict Sepsis Among Systemic Inflammatory Response Syndrome
    Kuroda, Kosuke
    Wake, Hidenori
    Mori, Shuji
    Hinotsu, Shiro
    Nishibori, Masahiro
    Morimatsu, Hiroshi
    CRITICAL CARE MEDICINE, 2018, 46 (04) : 570 - 576
  • [10] Time Course of Histidine-Rich Glycoprotein as a New Prognostic Biomarker for Sepsis: A Multicenter Prospective Observational Study
    Kawanoue, Naoya
    Kuroda, Kosuke
    Oiwa, Masahiko
    Suzuki, Satoshi
    Wake, Hidenori
    Nishibori, Masahiro
    Morimatsu, Hiroshi
    ANESTHESIA AND ANALGESIA, 2021, 132 (5S_SUPPL): : 245 - 246
12345