Based on the formation temperature and pressure, water chemistry, hydrodynamics, and the characteristics of water-rock interaction, Tertiary system can be divided into the shallow, the middle, the deep and the super deep water-rock interaction zones from top to bottom in Dongying Sag. The four water-rock interaction zones exist in the differences in the burial depth, formation, temperature and pressure, fluid dynamics, formation water chemistry and physic-chemical environment. The differences result in the differences of type, feature and intensity of water-rock interaction in each water-rock interaction zone. From the shallow water-rock interaction zone to the middle, the deep and the super deep water-rock interaction zone, the intensity of water-rock interaction varies from strong to weak, very stronger and stronger, and the type and intensity of water-rock interaction have an important effect on the porosity and permeability of reservoir in the deep and the super deep water-rock interaction zones.