Clinical applications of SPECT/CT after first I-131 ablation in patients with differentiated thyroid cancer

被引:22
|
作者
Jeong, Shin Young [1 ,2 ]
Lee, Sang-Woo [1 ,2 ]
Kim, Hae Won [1 ,2 ,3 ]
Song, Bong-Il [1 ,2 ,3 ]
Ahn, Byeong-Cheol [1 ,2 ]
Lee, Jaetae [1 ,2 ]
机构
[1] Kyungpook Natl Univ, Med Ctr, Dept Nucl Med, Taegu 702210, South Korea
[2] Sch Med, Taegu 702210, South Korea
[3] Keimyung Univ, Sch Med, Dept Nucl Med, Taegu, South Korea
基金
新加坡国家研究基金会;
关键词
COMPUTED TOMOGRAPHY/COMPUTED TOMOGRAPHY; INCREMENTAL VALUE; FOLLOW-UP; MANAGEMENT; SCINTIGRAPHY; CARCINOMA; THERAPY; IMAGES; FUSION; IMPACT;
D O I
10.1111/cen.12460
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective This study aimed to determine which thyroid cancer patients would benefit from SPECT/CT in addition to whole-body planar scintigraphy (RxWBS) for the detection and characterization of I-131 focal uptake after first ablation. Design and Patients Neck and thoracic SPECT/CT was performed in 187 patients with I-131 focal uptake suggestive of remnant thyroid tissue (Rem group, n = 152) or presumed lymph node (LN) metastases (mLN group, n = 35) on RxWBS. Clinical and pathologic parameters were analysed and compared in patients with and without additional SPECT/CT findings. Results wIn the Rem group, SPECT/CT revealed additional occult findings on RxWBS in 13 patients (8.6%). The serum thyroglobulin levels at the time of ablation were significantly higher in patients with additional SPECT/CT findings than in patients without additional findings (4.3 +/- 3.4 ng/ml vs 1.6 +/- 2.7 ng/ml, P = 0.001). In the mLN group, SPECT/CT demonstrated only remnant thyroid tissues without evidence of lymph node metastasis in 14 (40.0%) patients, whereas in the remaining 21 (60.0%) patients, I-131 uptake was confirmed in the corresponding neck and mediastinal lymph nodes on SPECT/CT. Conclusions Even in the Rem group, additional SPECT/CT could provide useful information for detecting hidden metastasis, especially in patients with high serum thyroglobulin levels. SPECT/CT should be recommended for patients with focal uptake lymph node metastasis on RxWBS.
引用
收藏
页码:445 / 451
页数:7
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