Physiological roles of SAPK/JNK signaling pathway

被引：113
|
作者：
Nishina, H [1 ]
Wada, T [1 ]
Katada, T [1 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Physiol Chem, Tokyo 1130033, Japan
来源：
JOURNAL OF BIOCHEMISTRY | 2004年 / 136卷 / 02期
关键词：
apoptosis; liver formation; ALAP kinase; SAPK/JNK; stress;
D O I：
10.1093/jb/mvh117
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) is activated by many types of cellular stresses and extracellular signals. Recent studies, including the analysis with knockout mice, have led to progress towards understanding the physiological roles of SAPK/JNK activation in embryonic development in addition to immune responses. SAPK/JNK activation plays essential roles in organogenesis during mouse development by regulating cell survival, apoptosis, and proliferation. Two SAPK/JNK activators, SEK1 and MKK7, are required for fetal liver formation and full activation of SAPK/JNK, which responds to various stimuli in an all-or-none manner. This article focuses on physiological roles of SAPK/JNK activation in fetal liver formation and in apoptosis regulation.
引用
收藏
页码：123 / 126
页数：4
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