Cocaine and amphetamine regulated transcript (CART) and the stress response

被引：93
|
作者：
Koylu, Ersin O. [1 ]
Balkan, Burcu
Kuhar, Michael J.
Pogun, Sakire
机构：
[1] Ege Univ, Ctr Brain Res, Dept Physiol, TR-35100 Izmir, Turkey
[2] Ege Univ, Sch Med, Dept Physiol, Izmir, Turkey
[3] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA
来源：
PEPTIDES | 2006年 / 27卷 / 08期
关键词：
CART; stress; corticotropin releasing factor; glucocorticoids; sex differences; HPA axis;
D O I：
10.1016/j.peptides.2006.03.032
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
CART is expressed abundantly in the hypothalamic paraventricular nucleus and locus coeruleus, major corticotropin releasing factor (CRF) and noradrenaline sources, respectively. There is a bidirectional relation between CART and hypothalamo-pituitary-adrenal axis activity. CART stimulates CRF, adrenocorticotropic hormone and glucocorticoid secretion, whereas CRF and glucocorticoids increase the transcriptional activity of the CART gene; adrenalectomy declines CART expression in the hypothalamus. Stress exposure modulates CART expression in hypothalamus and amygdala in rat brain in a region and sex specific manner. CART may be a mediator peptide in the interaction between stress, drug abuse, and feeding. The review discusses the established role of CART as it relates to the stress response. (c) 2006 Published by Elsevier Inc.
引用
收藏
页码：1956 / 1969
页数：14
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