Micafungin at Physiological Serum Concentrations Shows Antifungal Activity against Candida albicans and Candida parapsilosis Biofilms

被引：15
|
作者：
Guembe, M. [1 ,2 ]
Guinea, J. [1 ,2 ,3 ,4 ]
Marcos-Zambrano, L. J. [1 ,2 ]
Fernandez-Cruz, A. [1 ,2 ]
Pelaez, T. [1 ,2 ,3 ,4 ]
Munoz, P. [1 ,2 ,3 ,4 ]
Bouza, E. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Gregorio Maranon, Gen Hosp, Dept Clin Microbiol & Infect Dis, Madrid, Spain
[2] Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
[3] CIBER Enfermedades Resp CIBERES, Madrid, Spain
[4] Univ Complutense Madrid, Sch Med, Dept Med, Madrid, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 09期
关键词：
CENTRAL VENOUS CATHETER; BLOOD-STREAM INFECTION; IN-VITRO ACTIVITY; NATIONAL SURVEILLANCE; AMPHOTERICIN-B; SECULAR TRENDS; SUSCEPTIBILITY; ANIDULAFUNGIN; CASPOFUNGIN; MODEL;
D O I：
10.1128/AAC.02738-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We assessed the in vitro activity of micafungin against preformed Candida biofilms by measuring the concentration of drug causing the most fungal damage and inhibition of regrowth. We studied 37 biofilm-producing Candida spp. strains from blood cultures. We showed that micafungin was active against planktonic and sessile forms of Candida albicans strains and moderately active against Candida parapsilosis sessile cells. Concentrations of micafungin above 2 mu g/ml were sufficiently high to inactivate regrowth of Candida sessile cells.
引用
收藏
页码：5581 / 5584
页数：4
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