Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes

被引：25
|
作者：
Proshkina, Ekaterina N. [1 ,2 ]
Shaposhnikov, Mikhail V. [1 ,2 ]
Sadritdinova, Asiya F. [1 ]
Kudryavtseva, Anna V. [1 ]
Moskalev, Alexey A. [1 ]
机构：
[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia
[2] RAS, Inst Biol, Komi Sci Ctr, Ural Branch, Syktyvkar 167982, Russia
来源：
AGEING RESEARCH REVIEWS | 2015年 / 24卷
基金：
俄罗斯科学基金会;
关键词：
Drosophila melanogaster; Overexpression; Pro-longevity genes; EXTENDS LIFE-SPAN; ZN SUPEROXIDE-DISMUTASE; LONG-LIVED DROSOPHILA; OXIDATIVE STRESS; DIETARY RESTRICTION; MITOCHONDRIAL DYSFUNCTION; CAENORHABDITIS-ELEGANS; INCREASES RESISTANCE; INCREASED EXPRESSION; MEDIATES LONGEVITY;
D O I：
10.1016/j.arr.2015.08.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Drosophila is one of the most convenient model organisms in the genetics of aging and longevity. Unlike the nematodes, which allow for the detection of new pro-aging genes by knockout and RNAi-mediated knock-down, Drosophila also provides an opportunity to find new pro-longevity genes by driver-induced overexpression. Similar studies on other models are extremely rare. In this review, we focused on genes whose overexpression prolongs the life of fruit flies. The majority of longevity-associated genes regulates metabolism and stress resistance, and belongs to the IGF-1R, PI3K, PKB, AMPK and TOR metabolic regulation cluster and the FOXO, HDAC, p53 stress response cluster. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：218 / 231
页数：14
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