Dendritic cells in pregnancy and pregnancy-associated diseases

被引:26
|
作者
Wei, Ran [1 ]
Lai, Nannan [2 ]
Zhao, Lin [1 ]
Zhang, Zhen [1 ]
Zhu, Xiaoxiao [1 ]
Guo, Qiang [1 ]
Chu, Chu [1 ]
Fu, Xiaoxiao [1 ]
Li, Xia [1 ]
机构
[1] Shandong First Med Univ, Inst Basic Med, Lab Mol Immunol, Shandong Prov Hosp, 18877 Jingshi Rd, Jinan 250062, Shandong, Peoples R China
[2] Sun Yat Sen Univ, Sci Res Ctr, Affiliated Hosp 7, Shenzhen, Guangdong, Peoples R China
关键词
Dendritic cells; Maternal-fetal interface; Immunotolerance; Pregnancy; Pregnancy-associated diseases; PERIPHERAL LYMPHOID ORGANS; ANTIGEN-PRESENTING CELLS; MIXED LEUKOCYTE REACTION; NATURAL-KILLER-CELLS; CD4; T-CELLS; MATERNAL-FETAL; REGULATORY T; FUNCTIONAL-PROPERTIES; HUMAN DECIDUA; STEADY-STATE;
D O I
10.1016/j.biopha.2020.110921
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Dendritic cells (DCs) play a critical immuno-modulating role in pregnancy, which requires the maternal immune system to tolerate semiallogeneic fetus and at the same time to maintain adequate defense against pathogens. DCs interact closely with other immune components such as T cells, natural killer cells and macrophages, as well as the endocrine system to keep a pregnancy-friendly environment. Aberrant DC activities have been related to various pregnancy-associated diseases such as recurrent spontaneous abortion, preterm birth, pre-eclampsia, peripartum cardiomyopathy and infectious pregnancy complications. These findings make DCs an attractive candidate for prevention or therapy on the pregnancy-associated diseases. Here, we review recent findings that provide new insights into the roles of DCs in pregnancy and the related diseases. We also discuss the medical potentials to manipulate DCs in clinics. Whereas this is an emerging area with much work remaining, we anticipate that a better understanding of the role of DCs in maternal-fetal immunotolerance and a therapeutic manipulation of DCs will help women suffering from the pregnancy-associated diseases.
引用
收藏
页数:12
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