Molecular dynamics simulation of F-actin reveals the role of cross-linkers in semi-flexible filament assembly

被引：11
|
作者：
Nguyen, Lam T. [2 ,3 ]
Yang, Wei [4 ]
Wang, Qi [5 ]
Hirst, Linda S. [1 ]
机构：
[1] Univ Calif, Sch Nat Sci, Merced, CA 95344 USA
[2] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA
[3] Florida State Univ, MARTECH, Tallahassee, FL 32306 USA
[4] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA
[5] Florida State Univ, Dept Math, Tallahassee, FL 32306 USA
来源：
SOFT MATTER | 2009年 / 5卷 / 10期
基金：
美国国家科学基金会;
关键词：
ALPHA-ACTININ; POLYELECTROLYTES;
D O I：
10.1039/b817927a
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Hierarchically ordered protein networks are formed in solution by the self-assembly of F-actin, a semi-flexible biopolymer, in the presence of cross-linkers. We model the assembly of a 3D branching network of filament bundles using a coarse-grained molecular dynamics simulation, finding excellent agreement with experimental observations. We examine the role of cross-linker density on network morphology and filament curvature and observe a clear evolution from a loose single filament network to a network of bundles generated by cross-linker-induced branch points.
引用
收藏
页码：2033 / 2036
页数：4
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