Development of AVID100, a novel antibody-drug conjugate for the treatment of EGFR expressing solid tumors

被引：4
|
作者：
O'Connor-McCourt, M. [1 ]
Koropatnick, J. [2 ]
Maleki, S. [2 ]
Figueredo, R. [2 ]
Tikhomirov, I. [3 ]
Jaramillo, M. [4 ]
机构：
[1] Format Biol, R&D, Montreal, PQ, Canada
[2] Lawson Hlth Res Inst, Canc Res Program, London, ON, Canada
[3] Format Biol, R&D, Houston, TX USA
[4] Natl Res Council Canada, Human Hlth Therapeut, Montreal, PQ, Canada
来源：
EUROPEAN JOURNAL OF CANCER | 2016年 / 69卷
关键词：
D O I：
10.1016/S0959-8049(16)33037-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
450
引用
收藏
页码：S147 / S147
页数：1
相关论文
共 50 条
  • [1] Novel anti-EGFR antibody-drug conjugate AVID100: A phase 2a trial in patients with EGFR-overexpressing advanced solid tumors
    Melear, Jason
    Lakhani, Nehal
    O'Shaughnessy, Joyce A.
    Wilks, Sharon T.
    Khan, Saad
    Chandana, Sree R.
    Tolcher, Anthony W.
    Papadopoulos, Kyri P.
    Cole, Yvette
    Rivas, Karla
    Ghosh, Ria
    Sinclair, Sandra
    Lutz, Robert
    Nadler, Paul I.
    Wood, Debra L.
    Burtness, Barbara
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)
  • [2] A Phase Ia/IIa trial of AVID100, an anti-EGFR antibody-drug conjugate
    Lakhani, Nehal
    Chandana, Sreenivasa
    Tolcher, Anthony
    Cole, Yvette
    Rivas, Karla
    Sinclair, Sandra
    Nadler, Paul I.
    Wood, Debra L.
    Papadopoulos, Kyri P.
    CANCER RESEARCH, 2019, 79 (13)
  • [3] A Phase 1a/2a trial of AVID100, an anti-EGFR antibody-drug conjugate
    Tolcher, A.
    Papadopoulos, K.
    Cole, Y.
    Rivas, K.
    Chandana, S.
    Sinclair, S.
    Wood, D.
    Nadler, P. I.
    Lakhani, N.
    ANNALS OF ONCOLOGY, 2018, 29 : 8 - 8
  • [4] Development of a novel antibody-drug conjugate for the treatment of c-Kit expressing solid tumors and AML
    Abrams, Tinya J.
    Niu, Xiaohong
    Embry, Millicent
    Kline, Janine
    Patawaran, Montesa
    Fanton, Christie
    Ison-Dugenny, Marjorie
    Schneider, Tracy
    Miller, Kathy
    Wang, Zhen
    Ghoddusi, Majid
    Cohen, Steven
    Hong, E. Erica
    Lees, Emma
    Schleyer, Siew
    CANCER RESEARCH, 2015, 75
  • [5] Preclinical development of a novel camptothecin-based antibody-drug conjugate targeting solid tumors expressing Claudin-6
    Tsang, Nicola
    Veillard, Nicolas
    Horsley, Elizabeth
    Havenith, Karin
    Janghra, Narinder
    Zaitseva, Kristina
    Oblette, Cecile
    Kirby, Ian
    Hogg, Paul W.
    Zammarchi, Francesca
    de Haan, Lolke
    van Berkel, Patrick H.
    CANCER RESEARCH, 2024, 84 (06)
  • [6] Development and activity of a novel antibody-drug conjugate for the treatment of P-cadherin expressing cancers
    Menezes, Daniel
    Abrams, Tinya J.
    Karim, Christopher
    Tang, Yan
    Ying, Chi
    Miller, Kathy
    Fanton, Christie
    Ghoddusi, Majid
    Wang, Zhen
    Patawaran, Montesa
    Pryer, Nancy
    Lees, Emma
    Damiano, Jason
    CANCER RESEARCH, 2015, 75
  • [7] Preclinical development of a novel antibody-drug conjugate targeting "cold" tumors
    Kaplan, Angelo
    Attanasio, Nickolas
    Do, To Uyen T.
    Swaminathan, Sudha
    Bisht, Arnima
    Lou, San Lin
    Allen, Jason
    Boyd, Robert
    Ackroyd, James E.
    Feldman, Gleb
    Rohlff, Christian
    Dusek, Rachel L.
    CANCER RESEARCH, 2018, 78 (13)
  • [8] Development of a novel antibody-maytansinoid conjugate, IMGN289, for the treatment of EGFR-expressing solid tumors.
    Setiady, Yulius Y.
    Park, Peter U.
    Ponte, Jose F.
    Dong, Ling
    Skaletskaya, Anna
    Coccia, Jennifer A.
    Hong, Erica
    Clancy, Lauren
    Rui, Lingyun
    Pinkas, Jan
    Lutz, Robert J.
    Lambert, John M.
    Chittenden, Thomas D.
    CANCER RESEARCH, 2013, 73 (08)
  • [9] Discovery of A Novel EGFR-Targeting Antibody-Drug Conjugate, SHR-A1307, for the Treatment of Solid Tumors Resistant or Refractory to Anti-EGFR Therapies
    He, Kaijie
    Xu, Jianyan
    Liang, Jindong
    Jiang, Jiahua
    Tang, Mi
    Ye, Xin
    Zhang, Zhebin
    Zhang, Lei
    Fu, Beibei
    Li, Yan
    Bai, Chang
    Zhang, Lianshan
    Tao, Weikang
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (06) : 1104 - 1114
  • [10] Development of a Novel EGFR-Targeting Antibody-Drug Conjugate for Pancreatic Cancer Therapy
    Li, Zhuanglin
    Wang, Mingxue
    Yao, Xuejing
    Luo, Wenting
    Qu, Yaocheng
    Yu, Deling
    Li, Xue
    Fang, Jianmin
    Huang, Changjiang
    TARGETED ONCOLOGY, 2019, 14 (01) : 93 - 105
12345