Antioxidant and anti-diabetic potential of Passiflora alata Curtis aqueous leaves extract in type 1 diabetes mellitus (NOD-mice)

被引：36

作者：

Colomeu, T. C. ^{[1
]}

Figueiredo, D. ^{[1
]}

Cazarin, C. B. B. ^{[2
]}

Schumacher, N. S. G. ^{[1
]}

Marostica, M. R., Jr. ^{[2
]}

Meletti, L. M. M. ^{[3
]}

Zollner, R. L. ^{[1
]}

机构：

[1] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, BR-13083887 Campinas, SP, Brazil

[2] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, BR-13083862 Campinas, SP, Brazil

[3] Agron Inst Campinas, BR-13012970 Campinas, SP, Brazil

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2014年 / 18卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

Antioxidant capacity; Passiflora alata Curtis; Glutathione (GSH); Type 1 Diabetes mellitus; Non-obese diabetic mice; PROINFLAMMATORY CYTOKINES; OXIDATIVE STRESS; END-PRODUCTS; EXPRESSION; CONSTITUENTS; POLYPHENOLS; RECEPTOR; ASSAYS;

D O I：

10.1016/j.intimp.2013.11.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Leaves of Passiflora alata Curtis were characterized for their antioxidant capacity. Antioxidant analyses of DPPH, FRAP, ABTS, ORAC and phenolic compounds were made in three different extracts: aqueous, methanol/acetone and ethanol. Aqueous extract was found to be the best solvent for recovery of phenolic compounds and antioxidant activity, when compared with methanol/acetone and ethanol. To study the anti-inflammatory properties of this extract in experimental type 1 diabetes, NOD mice were divided into two groups: the P. alata group, treated with aqueous extract of P. alata Curtis, and a non-treated control group, followed by diabetes expression analysis. The consumption of aqueous extract and water ad libitum lasted 28 weeks. The treated-group presented a decrease in diabetes incidence, a low quantity of infiltrative cells in pancreatic islets and increased glutathione in the kidney and liver (p <0.05), when compared with the diabetic and non-diabetic control-groups. In conclusion, our results suggest that the consumption of aqueous extract of P. alata may be considered a good source of natural antioxidants and compounds found in its composition can act as anti-inflammatory agents, helping in the control of diabetes. (C) 2013 Elsevier B.V. All tights reserved.

引用

页码：106 / 115

页数：10

共 47 条

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