Urine Proteomics Analysis of Dairy Cows with Fatty Liver

被引：0
|
作者：
Xu, C. [1 ]
Sun, Y. H. [1 ]
Yang, W. [1 ]
Wu, L. [1 ]
Zhang, H. Y. [1 ]
Xia, C. [1 ,2 ,3 ]
机构：
[1] Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Daqing 163319, Peoples R China
[2] Northeast Agr Univ, Synerget Innovat Ctr Food Safety & Nutr, Harbin 150030, Peoples R China
[3] Heilongjiang Prov Univ, Key Lab Vet Med, Heilongjiang Bayi Agr Univ, Daqing 163319, Peoples R China
来源：
PAKISTAN VETERINARY JOURNAL | 2016年 / 36卷 / 01期
基金：
星火计划; 美国国家科学基金会;
关键词：
Biomarkers; Dairy cows; Fatty liver; Urine proteomics;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The objective of this study was to screen and identify differential proteins in the urine samples from cows with fatty liver disease (FLD) in order to provide new biomarkers for FLD. In this trial, twenty urine specimen were collected and assigned into two groups. After labelling with an i-TRAQ reagent, differential proteins in the urine samples were separated using two dimensional chromatography, and then identified by tandem mass spectrometry. The results showed that 110 differential proteins were screened: 50 were upregulated and 60 were down-regulated in the urine of cows with FLD. Among of these proteins, vitronection (VTN), neutrophil gelatinase-associated lipocatin (LCN2), prothrombin (F2), and clusterin (CLU) were the key regulatory factors determined by gene function, signaling pathway, and gene networks analysis. So, it is believed that the 4 key regulatory factors may become important biomarkers of FLD, which will provide new clinicopathologic insights into FLD in dairy cows. (c) 2015 PVJ. All rights reserved
引用
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页码：109 / 111
页数：3
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