Sequence variation and consensus sequence of V3 loop on HIV-1 gp120

被引：9
|
作者：
Tian, HJ
Lan, CH
Chen, YH [1 ]
机构：
[1] Tsing Hua Univ, Immunol Lab, Res Ctr Med Sci, Beijing 100084, Peoples R China
[2] Tsing Hua Univ, Minist Educ, Prot Sci Lab, Beijing 100084, Peoples R China
来源：
IMMUNOLOGY LETTERS | 2002年 / 83卷 / 03期
基金：
美国国家科学基金会;
关键词：
HIV-1; V3; loop; sequence variation; consensus sequence;
D O I：
10.1016/S0165-2478(02)00101-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mutation in the V3 loop of HIV-1 gp120 could affect syncytium formation, virus infectivity and neutralization. To acquire more information of the V3 loop mutation, we analyzed amino acid sequences of the V3 loop of 24 504 isolates from most HIV-1 clades (including A, B, C, D, E, F, G and H clades). The consensus sequence of the V3 loop of each subtype with the highest frequency emerging on each position is constituted and the conservation of each amino acid in this region is also calculated. Exploring the restricted mutation of the V3 region could help to understand mechanism of HIV entry and to develop new strategy against HIV-1. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：231 / 233
页数：3
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