Maternal caloric restriction partially rescues the deleterious effects of advanced maternal age on offspring

被引:24
|
作者
Gribble, Kristin E. [1 ]
Jarvis, George [1 ,2 ]
Bock, Martha [1 ,2 ]
Welch, David B. Mark [1 ]
机构
[1] Marine Biol Lab, Josephine Bay Paul Ctr Comparat Mol Biol & Evolut, Woods Hole, MA 02543 USA
[2] Northeastern Univ, Boston, MA 02115 USA
关键词
aging; caloric restriction; maternal effect; monogonont rotifer; LIFE-SPAN EXTENSION; DIETARY RESTRICTION; LONGEVITY; ROTIFERS; REPRODUCTION; INTERMITTENT; INHERITANCE; INDUCTION; EVOLUTION; PATHWAYS;
D O I
10.1111/acel.12217
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
While many studies have focused on the detrimental effects of advanced maternal age and harmful prenatal environments on progeny, little is known about the role of beneficial non-Mendelian maternal inheritance on aging. Here, we report the effects of maternal age and maternal caloric restriction (CR) on the life span and health span of offspring for a clonal culture of the monogonont rotifer Brachionus manjavacas. Mothers on regimens of chronic CR (CCR) or intermittent fasting (IF) had increased life span compared with mothers fed ad libitum (AL). With increasing maternal age, life span and fecundity of female offspring of AL-fed mothers decreased significantly and life span of male offspring was unchanged, whereas body size of both male and female offspring increased. Maternal CR partially rescued these effects, increasing the mean life span of AL-fed female offspring but not male offspring and increasing the fecundity of AL-fed female offspring compared with offspring of mothers of the same age. Both maternal CR regimens decreased male offspring body size, but only maternal IF decreased body size of female offspring, whereas maternal CCR caused a slight increase. Understanding the genetic and biochemical basis of these different maternal effects on aging may guide effective interventions to improve health span and life span.
引用
收藏
页码:623 / 630
页数:8
相关论文
共 50 条
  • [1] Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction
    Bock, Martha J.
    Jarvis, George C.
    Corey, Emily L.
    Stoner, Emily E.
    Gribble, Kristin E.
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [2] Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction
    Martha J. Bock
    George C. Jarvis
    Emily L. Corey
    Emily E. Stone
    Kristin E. Gribble
    [J]. Scientific Reports, 9
  • [3] Advanced maternal age and the impact on maternal and offspring cardiovascular health
    Cooke, Christy-Lynn M.
    Davidge, Sandra T.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2019, 317 (02): : H387 - H393
  • [4] Metyrapone Alleviates Deleterious Effects of Maternal Food Restriction on Lung Development and Growth of Rat Offspring
    David S. Paek
    Reiko Sakurai
    Aditi Saraswat
    Yishi Li
    Omid Khorram
    John S. Torday
    Virender K. Rehan
    [J]. Reproductive Sciences, 2015, 22 : 207 - 222
  • [5] Metyrapone Alleviates Deleterious Effects of Maternal Food Restriction on Lung Development and Growth of Rat Offspring
    Paek, David S.
    Sakurai, Reiko
    Saraswat, Aditi
    Li, Yishi
    Khorram, Omid
    Torday, John S.
    Rehan, Virender K.
    [J]. REPRODUCTIVE SCIENCES, 2015, 22 (02) : 207 - 222
  • [6] Effects of maternal caloric restriction and exercise during lactation
    Dewey, KG
    [J]. JOURNAL OF NUTRITION, 1998, 128 (02): : 386S - 389S
  • [7] Advanced Maternal Age and the Future Health of the Offspring
    Pariente, Gali
    Wainstock, Tamar
    Walfisch, Asnat
    Sheiner, Eyal
    Harlev, Avi
    [J]. FETAL DIAGNOSIS AND THERAPY, 2019, 46 (02) : 139 - 146
  • [8] Effects of advanced maternal age on cognitive and emotional development in offspring rats
    Han, Wei
    Dong, Xiangjun
    Song, Xiaojie
    Cheng, Li
    Xie, Lingling
    Chen, Hengsheng
    Jiang, Li
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2018, 353 : 218 - 226
  • [9] Effects of maternal food restriction on offspring body composition
    Desai, M
    Babu, J
    Gayle, D
    Day, L
    Beall, M
    Ross, M
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2003, 189 (06) : S227 - S227
  • [10] Advanced Maternal Age Impairs Myelination in Offspring Rats
    Han, Wei
    Pan, Ya'nan
    Han, Ziyao
    Cheng, Li
    Jiang, Li
    [J]. FRONTIERS IN PEDIATRICS, 2022, 10