Inhibitors of the TGF-β superfamily and their clinical applications

被引：29
|
作者：
Tsuchida, K. [1 ]
Sunada, Y.
Noji, S.
Murakami, T.
Uezumi, A.
Nakatani, M.
机构：
[1] Fujita Hlth Univ, Div Therapies Intractable Dis, Inst Comprehens Med Sci, Toyoake, Aichi 4701192, Japan
[2] Kawasaki Med Sch, Div Neurol, Dept Internal Med, Kurashiki, Okayama 7010192, Japan
[3] Univ Tokushima, Fac Engn, Dept Biol Sci & Technol, Tokushima 7708506, Japan
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 11期
关键词：
TGF-beta; activin; BMP; cancer; fibrosis; follistatin; myostatin; muscular dystrophy;
D O I：
10.2174/138955706778742759
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The transforming growth factor-beta (TGF-beta) superfamily includes TGF-beta s, activin, myostatin and bone morphogenetic proteins. Misregulation of the activity of TGF-beta family members is involved in pathogenesis of cancer, muscular dystrophy, obesity and bone and tooth remodeling. Natural inhibitors for the TGF-beta superfamily regulate fine-tuning of activity of TGF-beta family in vivo. In addition to natural inhibitors for the TGF-beta family, soluble forms of receptors for the TGF-beta family, blocking monoclonal antibodies and small chemical TGF-beta inhibitors have been developed. In this review, we summarize recent advances in our understanding of inhibitors for the TGF-beta superfamily and their medical applications.
引用
收藏
页码：1255 / 1261
页数：7
相关论文
共 50 条
  • [1] Engineering TGF-β superfamily ligands for clinical applications
    Kwiatkowski, Witek
    Gray, Peter C.
    Choe, Senyon
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2014, 35 (12) : 648 - 657
  • [2] Signal transduction by the TGF-β superfamily
    Attisano, L
    Wrana, JL
    SCIENCE, 2002, 296 (5573) : 1646 - 1647
  • [3] GDNF -: a stranger in the TGF-β superfamily?
    Saarma, M
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (24): : 6968 - 6971
  • [4] Tgf-β superfamily and limb regeneration: Tgf-β to start and Bmp to end
    Sader, Fadi
    Roy, Stephane
    DEVELOPMENTAL DYNAMICS, 2022, 251 (06) : 973 - 987
  • [5] Structural studies of the TGF-βs and their receptors - insights into evolution of the TGF-β superfamily
    Hinck, Andrew P.
    FEBS LETTERS, 2012, 586 (14) : 1860 - 1870
  • [6] The TGF-β superfamily in dendritic cell biology
    Seeger, Pascal
    Musso, Tiziana
    Sozzani, Silvano
    CYTOKINE & GROWTH FACTOR REVIEWS, 2015, 26 (06) : 647 - 657
  • [7] The Role of the TGF-β Superfamily in Myocardial Infarction
    Hanna, Anis
    Frangogiannis, Nikolaos G.
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2019, 6
  • [8] Cyclooxygenase inhibitors regulate the expression of a TGF-β superfamily member that has proapoptotic and antitumorigenic activities
    Baek, SJ
    Kim, KS
    Nixon, JB
    Wilson, LC
    Eling, TE
    MOLECULAR PHARMACOLOGY, 2001, 59 (04) : 901 - 908
  • [9] Intracellular signaling of the TGF-β superfamily by Smad proteins
    Kawabata, M
    Imamura, T
    Inoue, H
    Hanai, JI
    Nishihara, A
    Hanyu, A
    Takase, M
    Ishidou, Y
    Udagawa, Y
    Oeda, E
    Goto, D
    Yagi, K
    Kato, M
    Miyazono, K
    ANTICANCER MOLECULES: STRUCTURE, FUNCTION, AND DESIGN, 1999, 886 : 73 - 82
  • [10] The role of TGF-β superfamily signaling in neurological disorders
    Kashima, Risa
    Hata, Akiko
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 50 (01) : 106 - 120
12345