Using Wearable Sensor Technology to Measure Motion Complexity in Infants at High Familial Risk for Autism Spectrum Disorder

被引:30
|
作者
Wilson, Rujuta B. [1 ]
Vangala, Sitaram [2 ]
Elashoff, David [2 ]
Safari, Tabitha [1 ]
Smith, Beth A. [3 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, 760 Westwood Plaza, Los Angeles, CA 90095 USA
[2] David Geffen Sch Med, Dept Med Stat Core, 1100 Glendon Ave,Suite 1820, Los Angeles, CA 90024 USA
[3] Univ Southern Calif, Dev Neurosci & Neurogenet Program, Saban Res Inst,Dept Pediat,Keck Sch Med, Div Res Children Youth & Families,Childrens Hosp, Los Angeles, CA 90089 USA
关键词
motor development; autism spectrum disorder; wearable sensors; quantitative measures;
D O I
10.3390/s21020616
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Background: Motor dysfunction has been reported as one of the first signs of atypical development in infants at high familial risk for autism spectrum disorder (ASD) (HR infants). However, studies have shown inconsistent results regarding the nature of motor dysfunction and whether it can be predictive of later ASD diagnosis. This is likely because current standardized motor assessments may not identify subtle and specific motor impairments that precede clinically observable motor dysfunction. Quantitative measures of motor development may address these limitations by providing objective evaluation of subtle motor differences in infancy. Methods: We used Opal wearable sensors to longitudinally evaluate full day motor activity in HR infants, and develop a measure of motion complexity. We focus on complexity of motion because optimal motion complexity is crucial to normal motor development and less complex behaviors might represent repetitive motor behaviors, a core diagnostic symptom of ASD. As proof of concept, the relationship of the motion complexity measure to developmental outcomes was examined in a small set of HR infants. Results: HR infants with a later diagnosis of ASD show lower motion complexity compared to those that do not. There is a stronger correlation between motion complexity and ASD outcome compared to outcomes of cognitive ability and adaptive skills. Conclusions: Objective measures of motor development are needed to identify characteristics of atypical infant motor function that are sensitive and specific markers of later ASD risk. Motion complexity could be used to track early infant motor development and to discriminate HR infants that go on to develop ASD.
引用
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页码:1 / 13
页数:15
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