Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis

被引：320

作者：

Bos, Kirsten I. ^{[1
]}

Harkins, Kelly M. ^{[2
]}

Herbig, Alexander ^{[1
,3
]}

Coscolla, Mireia ^{[4
,5
]}

Weber, Nico ^{[3
]}

Comas, Inaki ^{[6
,7
]}

Forrest, Stephen A. ^{[1
]}

Bryant, Josephine M. ^{[8
]}

Harris, Simon R.

Schuenemann, Verena J. ^{[1
]}

Campbell, Tessa J. ^{[9
]}

Majander, Kerttu ^{[1
]}

Wilbur, Alicia K. ^{[2
]}

Guichon, Ricardo A. ^{[10
]}

Steadman, Dawnie L. Wolfe ^{[11
]}

Cook, Della Collins ^{[12
]}

Niemann, Stefan ^{[13
,14
]}

Behr, Marcel A. ^{[15
]}

Zumarraga, Martin ^{[16
]}

Bastida, Ricardo ^{[17
]}

Huson, Daniel ^{[3
]}

Nieselt, Kay ^{[3
]}

Young, Douglas ^{[18
,19
]}

Parkhill, Julian ^{[8
]}

Buikstra, Jane E. ^{[2
]}

Gagneux, Sebastien ^{[4
,5
]}

Stone, Anne C. ^{[2
]}

Krause, Johannes ^{[1
,20
,21
]}

机构：

[1] Univ Tubingen, Dept Archaeol Sci, D-72070 Tubingen, Germany

[2] Arizona State Univ, Sch Human Evolut & Social Change, Tempe, AZ 85287 USA

[3] Univ Tubingen, Ctr Bioinformat, D-72076 Tubingen, Germany

[4] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, CH-4002 Basel, Switzerland

[5] Univ Basel, CH-4003 Basel, Switzerland

[6] FISABIO Publ Hlth, Genom & Hlth Unit, Valencia 46020, Spain

[7] Inst Salud Carlos III, CIBER Ctr Invest Biomed Red Epidemiol & Publ Hlth, Madrid 28029, Spain

[8] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[9] Univ Cape Town, Dept Archaeol, ZA-7701 Rondebosch, South Africa

[10] UNMDP, FCEyN, Dept Biol, CONICET,Lab Ecologia Evolut Humana FACSO,UNCPBA, RA-7631 Quequen, Argentina

[11] Univ Tennessee, Dept Anthropol, Knoxville, TN 37996 USA

[12] Indiana Univ, Dept Anthropol, Bloomington, IN 47405 USA

[13] Forschungszentrum Borstel, D-23845 Borstel, Germany

[14] Forschungszentrum Borstel, German Ctr Infect Res, D-23845 Borstel, Germany

[15] McGill Univ, McGill Int TB Ctr, Montreal, PQ H3G 1A4, Canada

[16] CICVyA INTA Castelar, Inst Biotechnol, Buenos Aires, DF, Argentina

[17] Univ Nacl Mar del Plata, Fac Ciencias Exactas & Nat, Inst Invest Marinas & Costeras CONICET UNMcP, RA-7600 Mar Del Plata, Buenos Aires, Argentina

[18] Univ London Imperial Coll Sci Technol & Med, Dept Med, London W2 1PG, England

[19] MRC Natl Inst Med Res, Div Mycobacterial Res, London NW7 1AA, England

[20] Univ Tubingen, Senckenberg Ctr Human Evolut & Palaeoenvironm, D-72070 Tubingen, Germany

[21] Max Planck Inst Sci & Hist, D-07745 Jena, Germany

来源：

NATURE | 2014年 / 514卷 / 7523期

基金：

英国惠康基金; 瑞士国家科学基金会; 欧洲研究理事会; 美国国家科学基金会; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

TRANSMISSION; DISEASE; DNA;

D O I：

10.1038/nature13591

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact(1). This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World(2). Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch(3), although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-old mycobacterial genomes from Peruvian human skeletons, revealing that a member of the M. tuberculosis complex caused human disease before contact. The ancient strains are distinct from known human-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.

引用

页码：494 / +

页数：14

共 50 条

[1] Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
Kirsten I. Bos
Kelly M. Harkins
Alexander Herbig
Mireia Coscolla
Nico Weber
Iñaki Comas
Stephen A. Forrest
Josephine M. Bryant
Simon R. Harris
Verena J. Schuenemann
Tessa J. Campbell
Kerttu Majander
Alicia K. Wilbur
Ricardo A. Guichon
Dawnie L. Wolfe Steadman
Della Collins Cook
Stefan Niemann
Marcel A. Behr
Martin Zumarraga
Ricardo Bastida
Daniel Huson
Kay Nieselt
Douglas Young
Julian Parkhill
Jane E. Buikstra
Sebastien Gagneux
Anne C. Stone
Johannes Krause
Nature, 2014, 514 : 494 - 497
[2] Genomic analysis of pre-Columbian tuberculosis from the New World
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Bos, Kirsten I.
Herbig, Alexander
Coscolla, Mireia
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[3] PRE-COLUMBIAN TUBERCULOSIS
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[5] TUBERCULOSIS IN PRE-COLUMBIAN AMERICA
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[9] Polynesians in America: Pre-Columbian contacts with the New World
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[10] Polynesians in America: Pre-Columbian Contacts with the New World
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