A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes

被引：672

作者：

Nanda, I

Kondo, M

Hornung, U

Asakawa, S

Winkler, C

Shimizu, A

Shan, ZH

Haaf, T

Shimizu, N

Shima, A

Schmid, M

Schartl, M ^{[1
]}

机构：

[1] Univ Wurzburg, Dept Physiol Chem 1, Bioctr, D-97074 Wurzburg, Germany

[2] Univ Wurzburg, Inst Human Genet, Bioctr, D-97074 Wurzburg, Germany

[3] Univ Tokyo, Sch Integrated Biosci, Tokyo 1130033, Japan

[4] Keio Univ, Sch Med, Dept Biol Mol, Tokyo 1608582, Japan

[5] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 18期

关键词：

D O I：

10.1073/pnas.182314699

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The genes that determine the development of the male or female sex are known in Caenorhabditis elegans, Drosophila, and most mammals. In many other organisms the existence of sex-determining factors has been shown by genetic evidence but the genes are unknown. We have found that in the fish medaka the Y chromosome-specific region spans only about 280 kb. It contains a duplicated copy of the autosomal DMRT1 gene, named DMRT1 Y. This is the only functional gene in this chromosome segment and maps precisely to the male sex-determining locus. The gene is expressed during male embryonic and larval development and in the Sertoli cells of the adult testes. These features make DMRT1 Y a candidate for the medaka male sex-determining gene.

引用

页码：11778 / 11783

页数：6

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