Decreased brain coordinated activity in autism spectrum disorders during executive tasks: Reduced long-range synchronization in the fronto-parietal networks

被引：50
|
作者：
Velazquez, J. L. Perez [1 ,2 ,3 ]
Barcelo, F. [4 ]
Hung, Y. [1 ]
Leshchenko, Y. [1 ]
Nenadovic, V. [1 ]
Belkas, J. [1 ]
Raghavan, V. [1 ]
Brian, J. [5 ,6 ]
Dominguez, L. Garcia [1 ]
机构：
[1] Hosp Sick Children, Neurosci & Mental Hlth Programme, Brain & Behav Ctr, Div Neurol, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Dept Paediat, Toronto, ON M5G 1X8, Canada
[3] Univ Toronto, Inst Med Sci, Toronto, ON M5G 1X8, Canada
[4] Univ Islas Baleares, Dept Psychol, Palma de Mallorca 07122, Spain
[5] Hosp Sick Children, Autism Res Unit, Toronto, ON M5G 1X8, Canada
[6] Bloorview Res Inst, Toronto, ON, Canada
来源：
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY | 2009年 / 73卷 / 03期
关键词：
Brain synchronization; Magnetoencephalography; Autism; Executive functions; Neocortex; Phase synchrony; HIGH-FUNCTIONING AUTISM; CARD SORTING TEST; PHASE SYNCHRONIZATION; CORTICAL ACTIVATION; FRONTAL-CORTEX; CONNECTIVITY; INTERFERENCE; PERFORMANCE; COHERENCE; LOBE;
D O I：
10.1016/j.ijpsycho.2009.05.009
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
Current theories of brain function propose that the coordinated integration of transient activity patterns in distinct brain regions is the essence of brain information processing. The behavioural manifestations of individuals with autism spectrum disorders (ASD) suggest that their brains have a different style of information processing. Specifically, a current trend is to invoke functional disconnection in the brains of individuals with ASD as a possible explanation for some atypicalities in the behaviour of these individuals. Our observations indicate that the coordinated activity in brains of children with autism is lower than that found in control participants. Disruption of long-range phase synchronization among frontal, parietal and occipital areas was found, derived from magnetoencephalographic (MEG) recordings, in high-functioning children with ASD during the performance of executive function tasks and was associated with impaired execution, while enhanced long-range brain synchronization was observed in control children. Specifically, a more significant prefrontal synchronization was found in control participants during task performance. In addition, a robust enhancement in synchrony was observed in the parietal cortex of children with ASD relative to controls, which may be related to parietal lobe abnormalities detected in these individuals. These results, using synchronization analysis of brain electrical signals, provide support for the contention that brains of individuals with autism may not be as functionally connected as that of the controls, and may suggest some therapeutic interventions to improve information processing in specific brain areas, particularly prefrontal cortices. (c) 2009 Elsevier B.V. All rights reserved.
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页码：341 / 349
页数：9
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